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《Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease》 2015-09
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Changes of Serum Levels of L- Homoarginine and Asymmetric Dimethylarginine and Their Correlations with Cardiovascular Disease in Patients with Type 1 Diabetes Mellitus

ZHANG Jin;WEI Li;ZHANG Jian-jun;People's Hospital of Baoji;  
Objective To observe the changes of serum levels of L- homoarginine and asymmetric dimethylarginine,to investigate their correlations with cardiovascular disease in patients with type 1 diabetes mellitus. Methods A total of 89 patients with type 1 diabetes mellitus were selected as observation group in People's Hospital of Baoji from 2010 to 2012,and a total of 90 healthy people were selected as control group at the same time; according to the incidence of cardiovascular events during the 2- year fellow- up, patients of observation group were divided into three subgroups: A group( with severe cardiovascular events, n = 16), B group( with general cardiovascular events, n = 18), C group( without cardiovascular events,n = 55). Serum levels of L- homoarginine,asymmetric dimethylarginine and L- arginine at admission were compared between observation group and control group, while serum levels of L- homoarginine, asymmetric dimethylarginine, L-arginine,hs- CRP,TNF- α,IL- 6 were compared among A group,B group and C group,correlations between serum L-homoarginine,asymmetric dimethylarginine levels and incidence of cardiovascular events,serum levels of hs- CRP,TNF- αand IL- 6 were analyzed. Results No statistically significant differences of L- arginine was found between control group and observation group( P 0. 05),while serum L- homoarginine level of observation group was statistically significantly lower than that of control group,serum asymmetric dimethylarginine level of observation group was statistically significantly higher than that of control group( P 0. 05). No statistically significant differences of L- arginine was found among A group,B group and C group( P 0. 05),while serum L- homoarginine level of B group was statistically significantly lower than that of C group,serum levels of asymmetric dimethylarginine,hs- CRP,TNF- α and IL- 6 of B group were statistically significantly higher than those of C group( P 0. 05); serum L- homoarginine level of A group was statistically significantly lower than that of B group,C group,respectively,while serum levels of asymmetric dimethylarginine,hs- CRP,TNF- α and IL- 6 of A group were statistically significantly higher than those of B group and C group( P 0. 05). Pearson correlation analysis showed that,serum L- homoarginine level was negatively correlated with incidence of cardiovascular events( r =- 0. 458,P = 0. 000),serum hs-CRP level( r =- 0. 389, P = 0. 005), serum TNF- α level( r =- 0. 235, P = 0. 023) and serum IL- 6 level( r =- 0. 224,P = 0. 033), respectively; serum asymmetric dimethylarginine level was positively correlated with incidence of cardiovascular events( r = 0. 421,P = 0. 001),serum hs- CRP level( r = 0. 302,P = 0. 003),serum TNF- α level( r =0. 265,P = 0. 031) and serum IL- 6 level( r = 0. 228,P = 0. 032),respectively. Conclusion The serum L- homoarginine level of patients with type 1 diabetes mellitus is significantly lower, and is negatively correlated with the incidence of cardiovascular events; while serum asymmetric dimethylarginine level of patients with type 1 diabetes mellitus is significantly higher, and is positively correlated with the incidence of cardiovascular events; L- homoarginine and asymmetric dimethylarginine can cause endothelial dysfunction through affecting the NO production, and eventually induce cardiovascular disease.
【CateGory Index】: R587.1
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