Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Suzhou》 2001-04
Add to Favorite Get Latest Update

The Effects of IL-6 and its Receptors on Bone Loss in Postmenopausal Women

HUANG Xin 1,YANG Wei-wen 1,ZHANG Xue-guang 2 (1.Department of Obstetrics and Gynecology,The First Hospital Affiliated to Suzhou University,Suzhou 215006 China;?2.The Institute of Biologic Technology,Suzhou University,Suzhou 215007,China)  
Objective To investigate the effects of IL-6 and its receptors on bone loss in healthy women,and to assess the pathogenesis of the postmenopausal osteoporosis in women.Methods One hundred and one healthy women aged 31~72 including 64 sexual maturity women aged 31~52 were enrolled in four groups and 67 postmenopausal women,the years of menopause from 1 month to 23 years,were also enrolled in four groups.The bone mass of the lumbar-spine and femur were measured using dual-energy X-rays absorptionmetry;the serum E 2,FSH,BGP by radioimmunioassy(RIA);the serum IL-6,sIL-6R,sgp130 by ELISA;the serum AKP,calcium,phosphate by auto-biochemistry instrument.Results The BMD of lumbar-spine and right femur decreased following increase of age and the duration of menopause.Significant positive correlation was obserred between BMD and E 2,The serum IL-6,sIL-6R,sgp130 level was low,and stable before menopause.The level of IL-6,sIL-6R,sgp130 increased with variation of age and the duration of menopause.Significant negative correlation was observed between IL-6,sIL-6R,sgp130 and E 2,BMD.Serum AKP and BGP level was higher in postmenopausal women than that in sexiual maturity women.The serum calcium level increased significantly soon after menopausl,then decreased to the normal level The serum phosphate level had no difference in these groups.Conclusion The main cause of postmenopausal osteoporosis is the unbalance of the bone formation and resorption.
【Fund】: 卫生部科学基金资助课题 (卫 96 -2 -310 )
【CateGory Index】: R392.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved