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《Acta Academiae Medicinae Suzhou》 2005-03
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Study on Pathomorphology and Ultrastructure of Rat Pulmonary Fibrosis Model

WANG Xiang-ying,WU Shu-yan,LI Su-an,et al (Department of Electron Microscope, Medical School of Suzhou University, Jiangsu Suzhou 215007, China)  
Objective By quantitative analysis and evaluating the pathomorphology and ultrastructural changes in various periods of rat pulmonary fibrosis model,the evident for the preventive effect and therapeutic mechanism in treating pulmonary fibrosis are offered.Methods Pulmonary fibrosis was made by non-exposure intratracheal injection of Bleomycin. The pathomorphology and ultrastructure were observed, the weight of lungs and rats were recorded, then the pulmonary index (PI) was evaluated. Results The PI increased during the pulmonary fibrosis progress. The most badly alveolar inflammation occur in at 7th day and the obvious shrink of alveolar cavity and increase of collagen fibers at 28th day were found by means of the quantitative analysis. The infiltrating inflammatory cells and the increase of collagen fibers were able to be seen under the light microscope. The ultrastructure in most of them showed that the collagen fibers in alveolar septum was obviously increased and the honeycomb shape of pulmonary structure destroyed. Type Ⅱ alveolar epithelial cells hyperplasia also be seen. Conclusion The pulmonary fibrosis model induced by Bleomycin is typical in the development of alveolitis to pulmonary fibrosis.
【Fund】: 香港保健协会基金资助
【CateGory Index】: R563.9
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