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《Acta Academiae Medicinae Suzhou》 2005-03
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The Value of Prenatal Fetal Sex Determination by Detecting the Region Containing 6bp Difference of Amelogenin Gene in Maternal Plasma

LU Ya-chao, ZHU Bin, JIANG Hai-yan, et al (Division of Medical Genetics, Suzhou University, Jiangsu Suzhou 215007,China)  
Objective To set up a reliable non-invasive method for fetal sex determination.Methods DNA of X-Y homologous region containing 6bp different with that in the intron 3 of Amelogenin gene was amplified, then the genotype was detected by polyacrylamide gel electrophoresis and ethidium bromide. The fetus sex was determined according to the genotype.Results Thirty two plasma samples obtained from pregnant women were detected, 19 with male fetuses and 13 with female fetuses. Compared with the practical birth outcome, the coincidence rate was 96.88%.Conclusion Fetal sex determination by detecting Amelogenin gene 6bp difference in maternal plasma is a feasible and reliable method.
【CateGory Index】: R714.5
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【References】
Chinese Journal Full-text Database 1 Hits
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【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Chen Xuan*,Li Peiling,Wang Xueqing,et al.*Department of Obstetrics and Gynecology,the Second Affiliated Hospital,Harbin Medical College,Harbin 150086,China;Detection of amelogenin gene for the sex identification in fetus and patients with hermaphroditism.[J];Chinese Journal of Practical Gynecology and Obstetrics;2004-12
2 LIU Fu-min, FENG Xia , WANG Xiu-ying , et al. Department of Obstetrics and Gyanecology , Affiliated Hospital of Xuzhou Medical College , Xuzhou 221000 , China;Detection for fetal DNA in maternal plasma by fluorescence quantitative polymerase chain reaction[J];Chinese Journal of Perinatal Medicine;2005-06
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