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《Acta Academiae Medicinae Suzhou》 2005-03
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The Value of Prenatal Fetal Sex Determination by Detecting the Region Containing 6bp Difference of Amelogenin Gene in Maternal Plasma

LU Ya-chao, ZHU Bin, JIANG Hai-yan, et al (Division of Medical Genetics, Suzhou University, Jiangsu Suzhou 215007,China)  
Objective To set up a reliable non-invasive method for fetal sex determination.Methods DNA of X-Y homologous region containing 6bp different with that in the intron 3 of Amelogenin gene was amplified, then the genotype was detected by polyacrylamide gel electrophoresis and ethidium bromide. The fetus sex was determined according to the genotype.Results Thirty two plasma samples obtained from pregnant women were detected, 19 with male fetuses and 13 with female fetuses. Compared with the practical birth outcome, the coincidence rate was 96.88%.Conclusion Fetal sex determination by detecting Amelogenin gene 6bp difference in maternal plasma is a feasible and reliable method.
【CateGory Index】: R714.5
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