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《Suzhou University Journal of Medical Science》 2007-05
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Relationship Between the Levels of Serum 8-OHdG and Macrovascular Disease in Type 2 Diabetic Patients

LU Yan,LU Yi-qun,LI Hong-xia(1.Dept of Endocrinoloy,2.Dept of Cadiology,the First hosipital Affiliated to Suzhou University,Jiangsu Suzhou 215006,China)  
Objective To investigate the relationship of serum 8-hydroxy-guanine(8-OHdG) to intima-media thickness(IMT) of the carotid artery in subjects with type 2 diabetes(T2DM).Methods The levels of serum 8-OHdG were measured by ELISA in all 42 patients with type 2 diabetic and 20 cases in the normal control group,meanwhile the levels of IMT also were measured.The correlation between 8-OHdG and IMT were analysized in all patients with T2DM.Results The levels of serum 8-OHdG and IMT in patients with T2DM were significantly higher those in the control subjects(P0.05).There were positive correlation significantly between serum 8-OHdG and IMT(P0.05).Conclusion Elevated serum 8-OHdG may be one of probable risk factors in the early atherosclerosis in the patients with T2DM.
【CateGory Index】: R587.2
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【Co-references】
Chinese Journal Full-text Database 10 Hits
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