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《沈阳药学院学报》 1993-03
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EFFECTS OF EPIMEDIUM ICARIINE ON RABBIT AND DOG VASCULAR SMOOTH MUSCLE

Wang Min Liu Chonming Zhang Baofeng Dept. of Phys.  
EI can decrease the resting tension of blood vessel ring. The effect of EI,Ver, Pap, Phen on NE dose-response curves was studied in rabbit TA. While Phen competitively antagonized NE, EI, Ver,Pap also antagonized NE, but in a non-competitive manner. In Ca~(2+)-free Kreb-Henseleit solution. NE caused initial fast response which could not be caused by EI, while with Ca~(2+)added, Ca~(2+)-dependant response was markedly reduced by EI. Moreover, EI inhibited contraction evoked by K~+in rings of TA,MA and CA and inhibited the contraction of CBA ring induced by 5-HT,too. These findings suggest that El-induced vasodilation results from its inhibiting against receptoroperated and potential-dependant calcium influx.
【Key Words】： Epimedium Icariine Blood vessel ring Dose-response curves
【CateGory Index】： R965.4;;R972.4
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