The Effects of Epimedium Polysaccharides on the Immune Function of Immune-Depressed Mice

Xu Ying,Mu Xiaoshuo,Wang Gang,Sun Pengyue,Zhang Baofeng,Chen Yingjie Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015  

The effects of EPS on immune function of CY-treated mice and tumor-bearing mice were observed.The thymus index,hemolysin level,hemolytic ability of spleen plague forming cells and the number of WBC in the peripheral blood decreased by CY 80 mg/kg ip.EPS 50,25 mg/kg×7,ip, made the sleen index increase.But EPS had no significant change in the thyums index;EPS 50,25,12 5 mg/kg×7,ip could increase the values of hemolysin levels and hemolytic ability of the spleen plague forming cells of CY-treated mice;EPS 25,12 5 mg/kg×7,ip,could increase the number of WBC in the peripheral blood of CY-treated mice.Mice bearing the tumor decreased the immune responses.The thymus index,hemolysin level,hemolytic ability of the spleen plague forming cells and ability of delayed hypersensitivity were dereased.EPS 50,25 mg/kg×8,sc,enhanced the thymus index after a fall induced by the tumor-bearing with the increase of spleen index.EPS 50,25 mg/kg×8,sc,also increased the hemolysin levels,hemolytic ability of the spleen plague forming cells and delayed hypersensitivity of tumor-bearing mice.

【Key Words】： EPS immune-depressed CY-treated mice S\-\{180\}-bearing mice

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