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《Journal of Shenyang Pharmaceutical University》 2005-01
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Self-emulsifying preparation and chemical stability studying of ketoprofen

LIU Hua,LI San-ming,YUAN Yue,FENG Ming-fang,WU Qiong(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)  
Objective To develop the formula for self-emulsifying of ketoprofen and study stability of ketoprofen in the self-emulsifying drug delivery systems (SEDDS).Methods Through solubility experiments and constructing pseudo-ternary phase diagrams,the formula was screened.The chemical stability of the SEDDS formulations after temperature cycling and illumination was evaluated utilizing an HPLC assay.Results In the formula of ketoprofen,the oil,surfactant and cosurfactant were ethyl oleate,Tween 80 and Transcutol respectively.The average content of ketoprofen in the SEDDS after the temperature cycling was 99.0%,while they were 87.5% and 68.7% after 5 days and 10 days under illumination.Conclusion The formula for self-emulsifying of ketoprofen is ketoprofen,ethyl oleate,Tween 80 and Trandcutol,and the proportion of them is (w∶w∶w∶w=5.0∶40.0∶43.5∶11.5).The ketoprofen SEDDS need to be preserved without illumination.
【CateGory Index】: R94
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