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《Journal of Shenyang Pharmaceutical University》 2007-06
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Effects of gypenosides on cardiac function in diabetic cardiomyopathy rats

GE Min1,LIU Tong2,GUAN Su-dong3,MA Shan-feng3,WU Ying-liang1 (1.School of Pharmay,Shenyang Pharmaceutical University,Shengyang 110016,China;2.Pharmacological Laboratory,Liaoning Institute for Drug Control,Shenyang 110023,China;3.Bengbu Medical College,Bengbu 233030,China)  
Objective To investigate the therapeutic effects of gypenosides on the dysfunction of cardiac muscle in diabetes.Methods Fifty Sprague-Dawley rats were randomly divided into the following groups:Control,diabetic cardiomyopathy and diabetic cardiomyopathy treated with gypenosides.The diabetic cardiomyopathy in rats was induced by injecting streptozotocin(STZ,55 mg·kg-1,ip).Seven weeks after rats suffered from diabetes,they received gypenosides with different dosages(50,100,200 mg·kg-1·d-1) orally for six weeks.In the meanwhile,the pure water was given to one group of diabetic and normal rats as controls.Subsequently,the functions of cardiac muscle,such as left ventricular systolic pressure(pLVS),left ventricular end diastolic pressure(pLVED),maximal rate of increase and decrease of left ventricular pressure(±dp/dtmax)and the time reaching the maximal rate of increase of left ventricular pressure(t),as well as the activities of nitric oxide synthase(NOS),cardiac Ca2+ATPase and Na+-K+-ATPase were measured.The ultrastructure of cardiac muscle was examined by using electron microscopy.Results The images of cardiac muscles under electron microscopy in diabetic rats showed the degeneration of myofibrillae and the edema of mitochondria.pLVS,pLVED,±dp/dtmax and t,as well as the activities of NOS,cardiac Ca2+-ATPase and Na+-K+-ATPase in rats with diabetic cardiomyopathy were significantly lower than those in controls.The activities of NOS,cardiac ATPases and the function of cardiac muscles in diabetic rats with gypenosides treatment were higher than those without giving gypenosides.The degeneration of myofibrillae was not observed in diabetic rats with gypenosides treatment.Conclusions Gypenosides secure cardiac muscles and their function from diabetic impairment.
【CateGory Index】: R285
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China Proceedings of conference Full-text Database 1 Hits
1 DIAO Xue-zhi WANG Xiao-mei Department of Cardiology,Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,China;Effect of TXL superfine powder on diabetic myocardiopathy in rats:experiment study[A];[C];2008
Chinese Journal Full-text Database 5 Hits
2 ZHENG Qi bin 1,CHEN Jin he 2,WU Ji liang 3 (1.POSTGRADUATE,2.Department of Pharmacology,Medical College of Wuhan University, Wuhan 430071,China,3.Department of Pharmacology,Xianning Medical College);Effects of Gynostemma Pentaphyllam on Myocardial Ischemia Reperfusion Injury in Rats[J];Journal of Xianning Medical College;2002-02
3 ZHAO Ying, HU DaYi(Lab of Heart Center, Beijing Red Cross Chao Yang HospitalAffiliate of Capital University of Medicine, Beijing 100020);Effect of GP on action potentials,Lcalcium channel currents, sodium channel currents and potassium channel currents in isolated single ventricular myocyte of guinea pigs[J];CHINESE PHARMACOLOGICAL BULLETIN;1998-01
4 Zhou Jianzheng(Zhou JZ) ; Xiao Wenbin(Xiao WB) ; Zhang Fang(Zhang F) (Institute of pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850);Comparison of protective effects of gypenosides and ginsenosides on left ventricular relaxationduring acute myocardial ischemia in rats[J];CHINESE PHARMACEUTICAL JOURNAL;1996-04
5 Wang Linli,Wang Jiyue (Dept.of Pharmacy,Daping Hospitl,The Third Military Medical University,Chongqing 400042 China);Pharmacology Action and Progress In Clinic Application of Gynostemma Pentaphylum(Thumb) Mak[J];Information on Traditional Chinese Medicine;2002-04
Chinese Journal Full-text Database 10 Hits
1 LIU Xin-yan et al (School of Life Science,Nantong University,Nantong,Jiangsu 226007);Study on Effective Components Extraction and Antioxidant Capacities of Gynostemma pentaphyllum Makino[J];Journal of Anhui Agricultural Sciences;2008-31
2 TANG Jie,LIU Lian-sheng,XU Na-na,ZHAO Hai-quan(School of Life Science Anhui Agricultural University,Hefei 230036);Extraction methods of genomic DNA from Gynostemmna pentaphullum leaves[J];Journal of Anhui Agricultural University;2008-03
3 ZHANG Jin,WANG Chang-jun,XIE Jiang,CHEN Fang(Faculty of Pharmacology,Bengbu Medical College,Bengbu 233030,China);Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats[J];Journal of Bengbu Medical College;2007-04
4 LIU Shi-biao~(1,2),HU Zheng-hai~(1*) (1 Institute of Botany, Northwest University, Xi'an 710069,China;2 Institute of Ecology, Jishou University, Jishou,Hu'nan 416000,China);Histochemical Localization and Seasonal Change of Ginsenoside in Herb Tea (Gynostemma pentaphyllum)[J];Acta Botanica Boreali-occidentalia Sinica;2005-02
5 Rui Wen, Cen Yyingzhou, Xing Yingying, Su Miaoxian(Jinan university, Guangzhou 510632,China);Research on the Antihepatitis Herbal Medicine of Yao Nationality[J];Guangdong Chemical Industry;2005-03
6 ZHONG Xin,AI Jing,WANG Ning,et al (Department of Pharmacology,Harbin Medical University;Key Laboratory of Biopharmaceutical Engineering of Heilongjiang Province,Harbin 150086,China);Effect of DaMing capsule declining the plasma glucose of limosis on the type 2 diabetes rats[J];Journal of Harbin Medical University;2004-06
7 WANG Jin-hua,AI Jing,WANG Ning,et al(Department of Pharmacology,Harbin Medical University,Bio-Pharmaceutical Key Laboratory of Heilongjiang Province Harbin 150081,China);Effect of high glucose circumstance on the expression of L-calcium channel in the myocardial cells of neonate rats[J];Journal of Harbin Medical University;2006-02
8 TCM Collage, Hebei Medical University CAO Li jing ZHANG Jiang hua XU Zhan min (Shingjiazhuang050091);Effect of Renshenqiangxindiwan on Heart Function of Heart-Failure Dog with Sodium Pentobarbital[J];Journal of Hebei Traditional Chinese Medicine and Pharmacology;2001-03
9 ZHU Fang, LIU Fang, ZHEN Yan jun, et al . (Department of Pathology, Basic Medical College of Hebei Medical University, Shijiazhuang 050091, China);Efficacy of L-arginine in protecting diabetic rats from myocardial injury caused by free radicals[J];Basic Medical Sciences and Clinics;2003-02
10 JIN Ge MING Hai-xia LI Jun BAO Jing Director:QIU Tong (Gansu College of Chinese Medicine,Gansu 730000);Influence of Chinese herbal drugs with effects of replenishing qi and activating blood on heart function in rabbits with syndrome of heart-qi insufficiency[J];Journal of Beijing University of Traditional Chinese Medicine;2006-07
China Proceedings of conference Full-text Database 1 Hits
1 SONG Shu-liang, *JI Ai-guo, LIANG Hao (1 SDU Weihai International Biotechnology R&D Center Shandong Weihai 264209 2 pharmacy college of Shandong university Shandong Jinan 250012);The Protective Effect of Gynostemma Pentaphyllum Polysaccharides on Neural Cells Demaged by Glutamic Acid[A];[C];2006
Chinese Journal Full-text Database 10 Hits
1 XI Shu-gang1,2,ZHANG Xue-xin2,ZHANG Wen-jie2,WEI Zheng-ren3,ZHAO Chun-yan2 (1.Department of Endocrinology,First Hospital,Jilin University,Changchun 130021,China;2.Department of Physiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China;3.Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Protective effect of total arasolides of aralia elata(Miq) seem on cardiomyopathy in rats with early stage diabetes and its mechanism[J];Journal of Jilin University(Medicine Edition);2008-02
2 Han Xueshan, Yang Xufang, Bao Haihua (Mudanjiang Medical College 157011);The Pretective Function of Huanglian Detoxification Decoction onMyocardium Injury of Rats Induced By Streptozotocin[J];Quarterly of Forest By-product and Speciality In China;2004-02
3 WANG Mian, SU Sheng-ou, ZHANG Li-hui,et al. Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;The Effects of Rosiglitazone on Cardiomyocyte Apoptosis and Expression of Bax and Bcl-2 in Type 2 Diabetic Rats[J];Journal of Chinese Physician;2005-02
4 ZHANG Ping 1, LIANG Zi wen 1, WANG Hai hui 1, CAI Hong wei 1, ZHANG Su hua 2, WANG Shu ping 2 ( 1Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, 400038; 2Department of Endocrinology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400036, China);Effects of sodium vanadate on GLUT4 translocation in cardiac tissue of streptozotocin-induced diabetic rats[J];Acta Academiae Medicinae Militaris Tertiae;2004-12
5 TAN Hua-bing(Medical Department,The People's Hospital of Yunyang Medical College,Shiyan 442000,China);Effect of Fiveleaf Gynostemma Herb on hyperlipoidemia and hemorheological changes in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2007-15
6 WU Qi-nan,XIAO Qian,WU Ping,LI Long-ying,GAO Yuan (Department of Gerontology,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes[J];Acta Academiae Medicinae Militaris Tertiae;2007-19
7 CHEN Gang, LIN Li-xiang, ZHUANG Wei-te, YAO Jin, LI ANG Ji-xin, HUANG Hui-bin, LIN Fan, LIN Jian-li Department of Endocrinology, Fuj ian Provincial Hospital, Fuzhou 350001, China;Expression of energy metabolism-related genes in myocardial tissues of rats with diabetic cardiomyopathy[J];Journal of First Military Medical University;2002-11
8 CHEN Gang, LIN Li-xiang, ZHUANG Wei-te, YAO Jin, HUANG Hui-bin, LIANG Ji-xing, ZHANG Fan-lin, WEN Jun-ping, LI Lian-tao, LIN Miao, LIN Qing-min Department of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China;Effects of captopril on myocardial tissue energy metabolism and inflammation in rats with diabetic cardiomyopathy[J];Journal of First Military Medical University;2004-07
9 TANG Ling1 ZHENG Ying2 SHEN ZHu-Fang1 XIE Ming-ZHi1 1(Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union medical college,Beijing 100050) 2(Tiantan Hospital, Beijing, 100050);Antidiabetic effects of Vanadium[J];The Chinese Journal of Clinical Pharmacology;2001-04
10 Zhou Yanfang, Ouyang Jingping,Zhou Chenghui, et al Department of Pathophysiology, School of Medicine, Wuhan University,Wuhan 430071, China;Effects of Matrine on Cell Cyclin of Cardiac Fibroblasts Induced by Angiotensin Ⅱ[J];Journal of Hubei Medical University;2004-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 MA Shan feng,LU Zong lan,GUAN Su dong,LIU Gui lan (Department of Physiology,Bengbu Medical College,Anhui 233003 ,China) [;Antagonistic effect of gypenoside on diaphragm against doxorubicin cytotoxicity[J];JOURNAL OF BENGBU MEDICINAE COLLEGE;2000-05
2 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
3 HOU Xiao-Ping; JIA Guo-Liang; ZhAOKuan; JIA Guang-Xing;; DA Ji-Ping(Department of Cardiovasology, Xijing Hospital,Fourth Military Medical University, Xi'an 710033)(General Hospital of Air Force,PLA);Effects of gypenosides on intimal proliferation and expression of c-sis oncogene in rabbit iliac artery afterballoon deendothelialization[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-05
4 Zhang Xiaoli Liu Zhen Zhu Ziping Yang Puzhao Xie Renming (Department of Pharmacology, Shanxi Academy of Traditional Chinese Medicine Xi'an 71003);INFLUENCE OF GYPENOSIDES ON THROMBUS AND COAGULATION FUNCTION IN VIVO AND IN VITRO[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1999-Z1
5 Tang Chaoke, Sun Ming, Wen Gebo, Hu Bi, Liao Duanfang (Department of Diagnostics of Hengyang Medical College, Hengyang, 421001);Effect of Gypenosides on Mean Arterial Pressure and Nitric Oxide Levels in Rabbits with Endotosin Induced Shock[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1999-04
6 Lei Jianhua;et al(Department of Physiology Hengyang healthy academy,Hengyang,Hunan);Preventive Effect of Gypenoside Against Endotoxic Shock-Induced DIC in rabbit[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1994-02
7 HUANG Hong-Lin;YIN Wei-Dong;LIAO Duan-Fang;CHEN Jian-Xiong;TANG Xiao-Qing;LI Bo-Ping;CAO Jian-Guo and YU Lin (Division of Cardiopulmonary Pharmacology,Institute of Cardiovascular Diseases,Hengyang Medical College,Hengyang 421001,Chinas);Effect of Gypenosides on Formation of Atherosclerotic Plaque of Aorta in Hypercholesterolemic Rabbits[J];CHINESE JOURNAL OF ARTERIOSC LEROSIS;1998-04
9 Qin Zhangzheng;Zhao Lei;Bi Shirong;You Lan Chengdu Institute of Biology, Academia Sinica, Chengdu 610015;SAPONIN CONSTITUENTS AND RESOURCE OF GYNOSTEMMA PENTAPHYLLUM[J];Natural Product Research and Development;1992-01
10 Yan Junfeng,Li Jinrong,Hu Chuanzhen.Department of Stomatology,Hubei Provincial Corps Hospital,Chinese People's Armed Police Forces, Wuhan 430061,China;Induction of apoptosis by gypenosides in neck lymph node metastatic cell line derived from human oral squamous cell carcinoma[J];MEDICAL JOURNAL OF THE CHINESE PEOPLE'S ARMED POLICE FORCES;2000-05
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