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Effects of gypenosides on cardiac function in diabetic cardiomyopathy rats

GE Min1,LIU Tong2,GUAN Su-dong3,MA Shan-feng3,WU Ying-liang1 (1.School of Pharmay,Shenyang Pharmaceutical University,Shengyang 110016,China;2.Pharmacological Laboratory,Liaoning Institute for Drug Control,Shenyang 110023,China;3.Bengbu Medical College,Bengbu 233030,China)  
Objective To investigate the therapeutic effects of gypenosides on the dysfunction of cardiac muscle in diabetes.Methods Fifty Sprague-Dawley rats were randomly divided into the following groups:Control,diabetic cardiomyopathy and diabetic cardiomyopathy treated with gypenosides.The diabetic cardiomyopathy in rats was induced by injecting streptozotocin(STZ,55 mg·kg-1,ip).Seven weeks after rats suffered from diabetes,they received gypenosides with different dosages(50,100,200 mg·kg-1·d-1) orally for six weeks.In the meanwhile,the pure water was given to one group of diabetic and normal rats as controls.Subsequently,the functions of cardiac muscle,such as left ventricular systolic pressure(pLVS),left ventricular end diastolic pressure(pLVED),maximal rate of increase and decrease of left ventricular pressure(±dp/dtmax)and the time reaching the maximal rate of increase of left ventricular pressure(t),as well as the activities of nitric oxide synthase(NOS),cardiac Ca2+ATPase and Na+-K+-ATPase were measured.The ultrastructure of cardiac muscle was examined by using electron microscopy.Results The images of cardiac muscles under electron microscopy in diabetic rats showed the degeneration of myofibrillae and the edema of mitochondria.pLVS,pLVED,±dp/dtmax and t,as well as the activities of NOS,cardiac Ca2+-ATPase and Na+-K+-ATPase in rats with diabetic cardiomyopathy were significantly lower than those in controls.The activities of NOS,cardiac ATPases and the function of cardiac muscles in diabetic rats with gypenosides treatment were higher than those without giving gypenosides.The degeneration of myofibrillae was not observed in diabetic rats with gypenosides treatment.Conclusions Gypenosides secure cardiac muscles and their function from diabetic impairment.
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