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《Journal of Shenyang Pharmaceutical University》 2007-09
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Secondary metabolism product of fungus Trichoderma reesei

SUN Yi1,L A-li1,TIAN Li2,WEI Lan3,PEI Yue-hu1 (1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Department of Biological Pharmacy,Qingdao University of Science and Technology,Qingdao 266042,China;3.School of pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)  
Objective To study the secondary metabolism product of marine fungus Trichderma reesei systematically.Methods The compounds were isolated by means of silica gel column and HPLC chromatography.Their structures were determined on the basis of physicochemical evidences and spectral methods.Results Six compounds were isolated from the ethyl acetate extracts of the fermentation of marine fungus Trichoderma reesei,which were identified as cyclonerodiol(1),8,9-dihydroxy-megastigmatrienone(2),harzialactone A(3),3,6-dibenzylpiperazine-2,5-dione(4),3-isobutyl-8-hydroxylpyrrolopiperazine-2,5-dione(5),3-benzyl-8-hydroxyl-pyrrolopiperazine-2,5-dione(6).Conclusions Compounds 1-6 are isolated from marine fungus Trichderma reesei for the first time.
【Fund】: 国家海洋863计划资助课题(GrantNO.2001AA624020)
【CateGory Index】: R284
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