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《Journal of Shenyang Pharmaceutical University》 2009-03
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Antibacterial constituents of extracts of the aerial parts of Discocleidion rufescens

TIAN Ye1,2,TANG Hai-feng1,QIU Feng2,WANG Xiao-juan3,XUE Gai-jin2,LI Jun2(1.Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China;2.Shenyang Pharmaceutical University,Shenyang 110016,China;3.Department of Pharmacy,School of Stomatology,Fourth Military Medical University,Xi'an 710032,China)  
Objective To screen effective constituents of the aerial parts of Discocleidion rufescens against bacteria.Methods Compounds were isolated by bioassay-guided fractionation method with a combination of extraction and partition as well as multi-chromatography.Their structures were determined by spectral analysis and chemical evidences.Results Eight compounds were isolated from the antibacterial active fraction and identified as apigenin(1),luteolin(2),amentoflavone(3),paeonol(4),pheophytin a(5),132S-hydroxypheophytin a(6),β-stitosterol(7)and stigmasterol(8).Conclusions Compounds 46 are isolated from the plant of genus Discocleidion for the first time.The pharmacological results shows that compounds 16 exhibit certain inhibitory function.The activities of compound 4 are the highest.
【CateGory Index】: R284.1
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