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《Journal of Shenyang Pharmaceutical University》 2009-10
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Optimization of vinpocetine long-circulation liposome formulation by Box-Behnken experimental design

XING Chuan-feng,HU Hai-yang,YANG Chun-rong,JIN Yun-huan,ZHAO Xiu-li,CHEN Da-wei(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)  
Objective To develop and optimize vinpocetine long-circulation liposome.Methods Long-circulation liposome was prepared by the membrane hydration method.A three factor,three-level Box-Behnken design was used for the optimization procedure,with the soybean phosphatidylcholine concentration(ρ1),Tween80 concentration(ρ2)and soybean phosphatidylcholine to drug(ms∶md)as the independent variables,and the entrapment efficiency(Y1),the loading content(Y2),the particle diameter(d)as the response variable;the particle shape was measured by transmission electrical microscope.Results In the optimized vinpocetine long-circulation liposome formulation,the entrapment efficiency was 85.9%,the drug content was 18.5 mg·g-1,and the particle diameter was 213.4 nm.The observed responses were coincident with the predicted values of the optimized formulation,and the deviations of the measured values from the predicted ones were less than 10%.Conclusions The Box-Behnken experimental design facilitates the formulation and optimization of vinpocetine long-circulation liposome.
【CateGory Index】: R944
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