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《Journal of Shenyang Pharmaceutical University》 2010-10
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Separation and identification of new sucrose esters from root of Polygala tenuifolia Willd.

WU Xue-ying1,LIU Ming1,WU Ying-liang2,GUO Yuan-qiang3,LI Yu-shan1(1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2.School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China;3.College of Pharmacy,Nankai University,Tianjin 300071,China)  
Objective To study the constituents of the extract from the root of Polygala tenuifolia Willd.Methods The chemical constituents were isolated by silica,Sephadex LH-20 gel column chromatography and HPLC.Chemical characters and spectroscopic analysis were employed for the structural identification.Results Eleven compounds were obtained and their structures were identified as sibiricose A5(1),tenuifolioside A(α-D-glucopyranoside,3-O-[(2Z)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,2),tenuifolioside B(α-D-glucopyranoside,3-O-[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,3),tenuifolioside C(α-D-glucopyranoside,3-O-[(2Z)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,4),sibiricose A6(5),glomeratose A(6),sibiricaxanthone B(7),polygalaxanthone Ⅺ(8),1,2,3,7-tetramethoxyxanthone(9),onjixanthoneⅡ(10),and polygitol(11).Conclusions Compounds 24,named tenuifolioside A-C respectively,are new sucrose esters which have not been reported before.
【Key Words】: Polygala tenuifolia chemical constituent sucrose ester xanthone structure identification
【Fund】: 辽宁省自然科学基金资助项目(200620576)
【CateGory Index】: R284
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