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《Journal of Shenyang Medical College》 2019-04
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Efficacy of magnesium sulfate combined with labetalol for treatment of gestational hypertension and its effects on pregnancy outcome: a meta-analysis

SHAO Yaojun;YAO Yingshui;CHEN Yan;JIN Yuelong;ZHENG Tong;WANG Yanqiu;LIU Ling;Department of Preventive Medicine, Insititute of Chronic Disease Prevention and Control,Wannan Medical College;  
Objective: To systematically evaluate the efficacy of magnesium sulfate combined with labetalol in the treatment of gestational hypertension and its effects on pregnancy outcome. Methods: According to the inclusion and exclusion criteria, the related literatures about the treatment of gestational hypertension by magnesium sulfate combined with labetalol were searched in PubMed,CNKI, VIP and Wanfang databases. The meta-analysis was performed by using RevMan 5.3 and Stata 11.0 softwares. Results: A total of 23 randomized controlled trials with 1 371 cases in the experimental group and 1 360 cases in the control group were included in this meta-analysis. The results showed that compared with the control group, the total effective rate of the experimental group was higher(OR=4.68, 95% CI: 3.24-6.76, P0.01), the heart rate was better(MD=-4.80, 95%CI:-6.37--3.23, P0.01), the incidence of adverse reactions was lower(OR=0.59, 95%CI: 0.42-0.85, P=0.004), and the pregnancy outcomes such as postpartum hemorrhage(OR=0.30), uterine injury(OR=0.19), neonatal asphyxia(OR=0.23), and fetal distress(OR=0.26) were better. Conclusion:Magnesium sulfate combined with labetalol has better efficacy and good pregnancy outcomes in the treatment of gestational hypertension compared with magnesium sulfate alone.
【Fund】: 国家自然科学基金面上项目(No.81673266);; 安徽省自然科学基金项目(No.1808085QH283);安徽省自然科学基金项目(No.1808085MH297)
【CateGory Index】: R714.246
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 LAI Hui-chao;Department of Obstetrics and Gynecology,People′ s Hospital in Xingguo County of Jiangxi Province;;Analysis of Magnesium sulfate labetalol in the treatment of hypertension in pregnancy effect[J];中国当代医药;2015-31
2 TIAN Yujie;The Coal General Hospital in Shuang Yashan City;;Effect research of Labetalol Combined with Magnesium Treatmentin Gestational Hypertension[J];中国卫生标准管理;2015-01
3 FENG Yong-liang;PENG Ting-ting;WANG Fang;SU Tong;YUE Fu-juan;ZHANG Lin-rui;ZHANG Ya-wei;YANG Hai-lan;WANG Su-ping;School of Public Health,Shanxi Medical University;Division of Environmental Health Sciences,School of Public Health,Yale University;Obstetrics and Gynecology,the First Hospital of Shanxi Medical University;;Impact of hypertensive disorder complicating pregnancy on birth outcomes and its potential risk factors[J];中华疾病控制杂志;2014-02
4 ZHANG Meijuan Department of Gynaecology and Obstetrics,the Fourth People's Hospital of Haimen City in Jiangsu Province,Haimen 226141,China;Clinical experience of labetalol combined with magnesium sulfate in the treatment of hypertension in pregnancy[J];中国医药科学;2013-12
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 ZUO Yu;ZHENG Hai-xia;Department of Gynaecology,Baotou Qingshan District MCH;;Influencing Factors of Pregnancy Induced Hypertension and the Corresponding Clinical Treatment[J];中外医疗;2015-35
2 CHEN Bing;LIU Jia;LI Chundong;General Hospital of Air Force of Chinese PLA;;Evaluation of the Safety and Clinical Effects of Labetalol in Treatment of Severe Gestational Hypertension[J];河北医学;2015-11
3 LAI Hui-chao;Department of Obstetrics and Gynecology,People′ s Hospital in Xingguo County of Jiangxi Province;;Analysis of Magnesium sulfate labetalol in the treatment of hypertension in pregnancy effect[J];中国当代医药;2015-31
4 ZHANG Yi-Dong;WANG Qing-Qing;Deqing People's Hospital of Zhejiang Province;;Changes of levels of CD4~+CD25~+Foxp3~+ regulatory T cells in HDCP peripheral blood and its significance[J];中国免疫学杂志;2015-09
5 YANG Ying;PENG Zuoqi;MA Xu;National Research Institute for Family Planning;;Preconception heart rate and risk of preterm delivery in Chinese reproductive-aged women[J];中国生育健康杂志;2015-03
6 WU Xiao-qing;CHEN Lan-feng;ZHANG Jin-hua;NIU Jian-jun;ZHOU Yu-lin;XIE Rong-zhen;WANG Hao-ping;CHEN Guo-wei;CAI Li-xin;YE Xi;LI Xue-lai;LI Guo-wei;Center for Disease Control and Prevention of Xiamen City;College of Pubic Health,Fujian Medical University;Zhongshan Hospital Affiliated to Xiamen University;Hospital of Maternal and Child Healthcare of Xiamen City;Lianhua Hospital of Xiamen City;Center for Disease Control and Prevention of Huli District;Center for Disease Control and Prevention of Haicang District;;A case-control study of risk factors for low birth weight infants in Xiamen City[J];国外医学(医学地理分册);2015-01
7 WANG Yu-hong;WANG Zheng-yan;ZHANG Hai-yan;The Hospital of Gaobeidian City;;The effects of labetalol treatmenton on pregnancy-induced hypertension maternal and neonatal outcomes[J];临床合理用药杂志;2015-01
8 Sun Guangyu;Department of Obstetrics and Gynecology,the Seventh People's Hospital of Changzhou City,Jiangsu Province;;Observation on the influence factors of pregnancy induced hypertension syndrome and its clinical therapeutic effect[J];中国社区医师;2014-32
9 FANG Liansha;Department of Obstetrics and Gynecology, the Third People's Hospital of Huizhou City;;Study of the relationship betwen the neonatal myocardial injury and pregnancy induced hypertension syndrome[J];中国医药导报;2014-18
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 TIAN Yujie;The Coal General Hospital in Shuang Yashan City;;Effect research of Labetalol Combined with Magnesium Treatmentin Gestational Hypertension[J];中国卫生标准管理;2015-01
2 ZHU Ting;ZHANG Tian-ming;Department of Gynecology and Obstetrics,Maternal and Child Health Hospital of Xingcheng City in Liaoning Province;Medical College of Hubei Institute for Nationalities;;Effect observation of labetalol combined with magnesium sulfate in treatment of pregnancy induced hypertension syndrome[J];中国当代医药;2014-26
3 MO Daidi ZHAO Kewen WU Qiaoxian Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Dongguan City in Guangdong Province, Dongguan 523002, China;Clinical observation of hypertensive disorders in pregnancy[J];中国当代医药;2013-02
4 CHEN Hong-yu.Department of Gynaecology and Obstetrics,People's Hospital of Youyang,Chongqing 409800,China;Risk factors of hypertensive disorders complicating pregnancy[J];中华内分泌外科杂志;2012-04
5 LIU Hui,WANG Wei-ming,ZUO Qun.Department of Epidemiology and Health Statistics,College of Public Health of Hebei University(Baoding 071000,China);Risk factors of hypertensive disorder in pregnancy:a case-control study[J];中国公共卫生;2012-03
6 WANG Zhi-ming1,ZHUANG Ru-jin2,HAN Cong-hui3,YUAN Hong-wei4,CHEN Su-fen1,QIAO Su-zhen1,XIE Ya-chun1,FU Zhi-wei1,GUO Lin1,ZONG Yu-xi2,ZHANG Hui-ying1.(1 Department of Child and Adolescent Health and Maternal Health Care,Public Health College,Harbin Medical University,Harbin,Heilongjiang 150081,China;2 Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China;3 Harbin Red Cross Hospital,Harbin,Heilongjiang 150010,China;4 Maternal and Child Care Service Centre of Mudanjiang,Mudanjiang Heilongjiang,157000,China);Study on correlation between adverse outcome hypertension disorder complicating pregnancy and umbilical artery flow of fetus[J];中国儿童保健杂志;2012-03
7 ZHOU Ai-hua.Lengshuijiang People's Hospital of Loudi,Loudi Hunan 417500,China.;Clinical efficacy of Labetalol and magnesium sulfate in treatment of hypertensive disorders in pregnancy[J];临床和实验医学杂志;2011-11
8 DENG Geng1,JIANG Weihong1,LI Ying2,LUO Qiong3,GUO Yunzhong1,TAN Lihua1(1.Department of Cardiology,Third Xiangya Hospital,Central South University,Changsha 410013;2.Department of Health Bureau of Yuelu District,Changsha 410013;3.Maternal and Child Health Institute of Yuelu District,Changsha 410006,China);Epidemiological status and risk factors for hypertensive disorder complicating pregnancy in a district in Changsha[J];中南大学学报(医学版);2011-04
9 RUAN Yan,ZHAI Gui-rong,WANG Qi.(Department of Obstetrics,Affiliated Obstetric Hospital,Capital Medical University,Beijing 100026,China);EFFECT OF LABETALOL ON PREGNANT WOMEN AND FETUS IN THE TREATMENT OF HYPERTENSION DURING GESTATIONAL PERIOD[J];现代预防医学;2008-12
10 XU Dong-mei, SUN Huai-jun, LI Kun, et al. Department of Neurology, Zibo Coal Central Hospital, Zibo 255120, China;Analysis of the risk factors for cerebral infarction resulting from transient ischemic attack[J];临床神经病学杂志;2006-03
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