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《JOURNAL OF SHENYANG MEDICAL COLLEGE》 1995-01
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STUDY ON PHARMACOKINETICS PARAMETERS OF ANDROGRAPHOLIDE IN RABBIT PLASMA BY CHEMILUMINESCENCE

Wang Baoqi Pang Zhigong Wang Congying Xi'an Medical University,Xi'an 710061 Yin Hong Shanxi Xingping Auialitin and Spaceflight Ministry l45 Hospital  
Andrographolide is one of the effective constituents of andrographis panicuiflta nees. Inorder to study the relationship between pharmacokinetics and pharmacodynamics,drug-bloodconcentration was monitored by a highly sensitive organic coupled chemiluminescence tech-nique and a series of pharmacokinetic parameters were obtained. The results suggest that an-drographolide can rapidly reach peak concentration,its elemination half-life is long,and thebioavailability is high.The main Pharmacokinetic parameters are Ka=1.34h-1±0.08,K1,2=0.336h-1±0.01,K2,1=0.633h-1± 0.06t1/2(α)=10.692h±0.07,t1/2(β)=12.12h±1.9,AUC=501.09μg·h/mL± 9.8。
【Fund】: 国家自然科学资金
【CateGory Index】: R285.5
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Guo Heming (Department of Basic Science of Anhui Medical University,Hefei,230032)Ma Xiaoyan (Epidemic Prevention Station of Anhui Province,Hefei,230061);The Toxicity of Perilla Frutescens[J];Journal of Anhui University(Natural Sciences);1997-03
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