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《Practical Preventive Medicine》 2003-01
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The Vicissitudes of Mycoplasma's Antibiotic-resistance in Shenzhen

Chang Gaifeng 1,Ma Zhichao 2 (The People's Hospital of Xixiang in Baoan District,Shenzhen City)  
Objective The vicissitudes of Mycoplasma's antibiotic-resistance between 2000 and 2002 in Shenzhen was explored. The antibiotic-resistance between Mycoplasma's preliminary diagnosis and it's reexamination was compared so as to provide reliable evidence for the reasonable drug use and avoid the abuse of antibiotics and the repeated infection. Methods Adopting the broth dilution, we supervised the antibiotic-resistance of 1062 strains of Mycoplasma successively, and analyzed the results of the three years'. After three passage cultivation, we inoculated the pure-culture to fluid medium, cultivated them for 24-48 hours under 37 centigrade, and detected their antibiotic-resistance. Result To the majority of antibiotics, the resistance rate of Mycoplasma increased during the three years. The difference of resistance rate between Mh and Uu has statistical significance. In Uu, the highest resistance rate is to Pefloxacin, which is 65.70%, and the lowest resistance rate is to Josamycin(2.33%); In Mh, the highest resistance rate is to Roxithromycin, which is 28.49%, and the lowest one is to Pefloxacin(1.30%). The antibiotic-resistance rate of Mycoplasma's reexamination is higher than that of the Mycoplasma's preliminary diagnosis. Conclusion The antibiotic-resistance rate of Mycoplasma increased year by year. It has three main reasons: (1)the abuse of antibiotics;(2)the inappropriate drug use in Uu infectors, which can result in mix-infection with Mh;(3)the appearance of multi antibiotic-resistance. We suggest that when Mycoplasma infection is suspected, cultivation, identification, classification of the type of Mycoplasma, and drug sensitivity test in vitro must be of the first priority so that antibiotics be selected reasonably.
【Fund】: 深圳市宝安区科技局立项项目 (2 0 0 1 B0 65)
【CateGory Index】: R446.5
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