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《Practical Preventive Medicine》 2006-02
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Clinical Distribution of Nosocomial Infection and Antimicrobial Resistance

YIN Ming~1,ZENG Jian-gao~2,ZHANG Hua~2(1.Center for Disease Control and Prevention of Yiyang City,Yiyang 413000,Hunan,China;2.Yiyang Municipal Central Hospital,Yiyang 413000,Hunan,China)  
Objective To study the distribution of pathogens in nosocomial infection and the antimicrobial resistance in a certain hospital in the recent 5 years. Methods Pathogenic microbial and antimicrobial sensitivity tests were conducted for samples,which were gathered from respective department between July 2000 and May 2005. Results Three hundred and seven strains pathogens in nosocomial infection were from respiratory tract,gastrointestinal tract,urinary tract,and blood samples.Gram-negative bacillus was the majority one(50.81%),followed by Grame-positive bacteria(25.41%) and fungi(23.78%).The antimicrobial spectrum showed that the resistance rate of Staphylococcus aureus,Staphylococcus epidermidis,Staphylococcus haemolytics to Imipenem was more than 24%;the resistant rate to Penicillin G,Oxacillin,Ampicillin,Cefazolin,Chloramphenicol,Erythromycin reached up to 57%.The resistant rate of the isolates of Gram-negative bacilli to Imipenem,Amikacin,Pipracillin/Tazobactam,Ceffazidime,Cefotaxima,and Levofloxacin was the lowest;and the resistant rate to Ampicillin was the highest. Conclusion The pathogens in nosocomial infection are mainly the opportunistic pathogenic bacteria and mostly Gram-negative bacilli.The infection due to fungi shows an increasing trend.It should pay attention to the pathogenic detection and rational use of antimicrobial agent.
【CateGory Index】: R446.5
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