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《Practical Preventive Medicine》 2007-01
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Studies on Distribution of HLA-A/B Antigens and Treatment in Recurrent Spontaneous Abortion

LI Li-xin, LUO Qi-zhi, YU Ping, et al. (Department of Immunology, Xiangya Medical College, Central South University, Changsha 410078, Hunan)  
Objective The HLA-A/B sharing in women with recurrent spontaneous abortion(RSA) and its effective treatment method were studied. Methods HLA typing in 47 couples with unexplained fetal loses were compared with those of 54 couples of normal controls, and their husbands' or donors' leukocytes suspension were applied for treatment. Results HLA sharing was significantly decreased in the patients(57.45%) as compared with the normal controls(RR=3.13, χ2 =7.76, P0.01). HLA-B35 antigen frequency in the patients(0/108) was significantly lower than that of the controls(10/94; RR=0.05, P=0.00156, Pc=0.028). Successful pregnaney was obtained in 74.07% of these RSA women after immunization with their husbands' or donors' lymphocytes suspension. Conclusion RSA is associated with increased HLA sharing. HLA-B35 contributes the protective role in RSA. Application of husband's or donors' leukocytes suspension in treatment of RSA is effective.
【CateGory Index】: R714.21
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