Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Practical Preventive Medicine》 2007-01
Add to Favorite Get Latest Update

Studies on Distribution of HLA-A/B Antigens and Treatment in Recurrent Spontaneous Abortion

LI Li-xin, LUO Qi-zhi, YU Ping, et al. (Department of Immunology, Xiangya Medical College, Central South University, Changsha 410078, Hunan)  
Objective The HLA-A/B sharing in women with recurrent spontaneous abortion(RSA) and its effective treatment method were studied. Methods HLA typing in 47 couples with unexplained fetal loses were compared with those of 54 couples of normal controls, and their husbands' or donors' leukocytes suspension were applied for treatment. Results HLA sharing was significantly decreased in the patients(57.45%) as compared with the normal controls(RR=3.13, χ2 =7.76, P0.01). HLA-B35 antigen frequency in the patients(0/108) was significantly lower than that of the controls(10/94; RR=0.05, P=0.00156, Pc=0.028). Successful pregnaney was obtained in 74.07% of these RSA women after immunization with their husbands' or donors' lymphocytes suspension. Conclusion RSA is associated with increased HLA sharing. HLA-B35 contributes the protective role in RSA. Application of husband's or donors' leukocytes suspension in treatment of RSA is effective.
【CateGory Index】: R714.21
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Renmei 1, LIU Lu 1,Xu Jingji 2, et al (Yanan Hospital Kunming,Kunming 650051);Immunological Studies and Leukocytes Immunization In Women With Unexplained Recurrent Spontaneous Abortion[J];JOURNAL OF PRACTICAL OBSTETRICS AND GYNECOLOGY;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Jun, Shi Xiaohong Blood center of Shandong Province, Jinan, China, 250014;Clinical treatment of RA by Leuco - PE[J];Qilu Journal of Medicall Aboratory Sciences;2004-02
2 ZHAO Ying, WU Yan, FU Sheng-miao, et al. (Medical Research Center of Hainan Provincial People's Hospital, Haikou 570311, Hainan, P. R. China);Analysis of HLA and its haplotype gene frequency in Han nationality in Hainan Province[J];China Tropical Medicine;2004-06
3 Huang Zheng-ji et al.Department of Dermatology, Hua Shan Hospital, Shanghai Medical University;THE ASSOCIATION BETWEEN BEHCET'S DISEASE AND HLA[J];;1987-04
4 Pei Ji Li Mingzhang Liu Gongzhi Liu Keying Tang Zongyin et al. Institute of Blood Transfusion,Chinese Academy of Medical Sciences;HLA ANTIGEN PROFILE IN HAN RACE POPULATIONS IN SOUTH CHINA[J];;1988-03
5 Luo, Chao-quan Guo, Jun-ruing Yang, Ying-hao Wu, Xin-yao~* Liu, Xi-wen~1 (Department of Biochemistry, Sun Yat-Sen University of Medical Sciences * Department of Forensic Biology, Sun Yat-Sen University of Medical Sciences Guangzhou, 510089);Studying on Genetic Polymorphism of Apoliporotein B Gene 3'-End VNTR in the Han Nationality of Guangdong Province[J];;1993-04
6 Chen, Hong-Shu; Chen, Song;Cao,Ting-Bing; Gan, Li-Xia(Genetic Engtrsering Lab,Third Millitary Medreal College, Chongqing 630038);Studies on the Regulation of h-IL-3 Gene Expression[J];;1995-01
7 Huang Xiao-Yu;Wang Ya-Xin;Wang Fu-Qing;Chen Shi-Shu(Department of Biochemistry and Laboratory of Molecular Biology, Deportment of Immunology, Shanghai Second Medical University, Shanghai 200025);Analysis of the Polymorphism at HLA-DRB1 Gene Locus by PCR-RFLP[J];;1996-06
8 LIU Meng-li,LIU Sheng,QI Jun,WEI Xiao-qian(Shaanxi Provincial Blood Center,Shaanxi Xi'an 710061,China);Analysis HLA-B~* 53 Frequency in Xi'an and Study the High Resolution Result[J];Journal of Modern Laboratory Medicine;2006-03
9 Department of Clinical Microbiology and Immunology, Guiyang Medical College(Guiyang 550004) Jiang Hongmei Wang Yongxia;The linkage analysis of HLA-DRB_1 and polymorphisms of HLA-DM gene[J];Shaanxi Medical Journal;2008-09
10 LUO Qizhi, LI Lixin, SUN Kezhu,et al. (Department of Immunology,Xiang Ya Medical College,Central South University,Changsha 410078,China);Investigation of the Relationship between Ankylosing Spondylitis and HLA-B27 in Hunan Province[J];Practical Preventire Medicine;2002-03
China Proceedings of conference Full-text Database 1 Hits
1 LIU Zhong,WANG Xiao-long,XUE Peng,HE Yong-xin,CHEN Yu-lin(College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China);Research on the Exon 3 of Leption Gene Polymorphism in sheep[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 FU Zheng ying, CHEN Ning (The Affiliated Hospital, Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China.);HLA-G and maternal-fetal immune tolerance during pregnancy[J];Foreign Medical Sciences Section of Maternal and Child Health;2003-06
2 PENG Bing,LIU Shu-yun(Department of Gynecology and Obstetrics,The Second Huaxi Hospital, Sichuan University,Sichuan Chengdu 610041,China);Progress in study on relationship between nonclassical human leucocyte antigenI and immunology in pregnancy[J];Chinese Journal of Maternal and Child Health Research;2006-03
3 XUE Song-guo,YANG Jue-qin,YAO Fang-juan,XU Ling-di,FAN Li-an(Shanghai Jiaotong University School of Medicine,Shanghai Institute of Immunology,Shanghai 200025,China);Study on the polymorphism of the 14 bp deletion of HLA-G allele in patients with recurrent spontaneous abortion of unknown origin and normal deliveries[J];Current Immunology;2006-04
4 MA Wei~(1,2),ZHOU Chang-ju~1(1.Department of Obstetrics and Gynecology,Third Xiangya Hospital,Central South University,Changsha 410013;2.Medical College of Northwest Nationality University,Lanzhou 730030,China);Research progression of HLA-G polymorphism in human reproduction[J];International Journal of Pathology and Clinical Medicine;2006-03
5 HUANG Cheng-fang~(1),WU Xiong-wen~(2) (1.College of Medical Science, Wuhan University of Science and Technology, Wuhan 430080,China; 2.Tongji Medical College ,Huazhong University of Science and Technology,Wuhan 430030,China);Research Progress in Soluble HLA-I[J];Journal of Wuhan Yejin University of Science and Technology;2004-03
6 LIN Qide *,LU Peihua,WANG Xipeng,et al *Department of Obstetrics and Gynecology,Renji Hospital Affilated to Shanghai Second Medical University,Shanghai 200001, China;The study on human leucocyte antigen DQ region genes polymorphism in unexplained habitual abortion patients[J];Chinese Journal of Obstetrics and Gynecology;2001-05
7 ZHENG Mei-ling*, NIU Li-yun. *Department of Obstetrics and Gynecology, First Clinical College, Shanxi Medical University, Taiyuan 030001,China;Association of soluble human leukocyte antigen DQB1 with recurrent spontaneous abortion[J];Chinese Journal of Obstetrics and Gynecology;2006-03
8 MENG Haiying, HOU Yiping. (School of Forensic and Pre clinical Medicine, Sichuan University, Chengdu, Sichuan, 610041 P.R.China.);Genetic polymorphisms, function and clinical effect of HLA-G[J];Chinese Journal of Medical Genetics;2002-04
9 ZHAO Liang,FAN Li An,YANG Jue Qin et al.Shanghai Second Medical University,Shanghai Institute of Immunology,Shanghai 200025;Study on association of HLA-E with recurrent spontaneous abortion[J];Chinese Journal of Immunology;2001-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LinQide,ZhaoAimin,ZhouHanchun,etal.RenjiHospital,ShanghaiSecondMedicalUniversity,Shanghai200001;ImmunotherapyofPrimaryHabitualAbortion[J];Chinese Journal of Obstetrics And Gynecology;1996-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved