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Anti-enterovirus Effects of Aqueous Extracts From Caulis Spatholobi in Vitro

GUO Jin-peng,PANG Ji,WANG Xin-wei,et al.(Disease Prevention and Control Institute of the Chinese People's Liberation Army,Beijing 100071,China)  
Objective To assay the anti-enterovirus effects of the aqueous extracts from Caulis spatholobi in vitro and its antiviral mechanism.Methods The antiviral effects of the aqueous extracts from Caulis spatholobus on enterovirus and its cytotoxicity on Vero cells were assessed by CPE and MTT methods.Antiviral mechanism of the extracts was also investigated by four different ways.Results The cytotoxicity of extracts on Vero cells was CC50 ≥ 250 ug/ ml.The median effective concentration(IC50,50% inhibition concentration) of the aqueous against replications of Coxsackie virus B3,Coxsackie virus B5,ECHO virus 9,ECHO virus 29,and Polio virusⅠwas 60.8,47.1,14.8,65.5,and 29.1 ug/ml in Vero E6 cells respectively,and the therapeutic index(TI=CC50/IC50) of AE was 4.1,5.3,16.9,3.8,and 8.6 respectively.ConclusionThe experiment shows that the aqueous extracts from Caulis spatholobi not only inhibit the CVB3 replication in cells but also kill the tested viruses directly through restraining them via getting into cells or absorbing on cells surface.
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