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《Practical Preventive Medicine》 2008-02
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Effects of Radix Potentilla anserine and Ophiopogon japonicus Extract on Experimental Diabetes in Mice

XIA Yong,DONG Xiao-lan,LIN Xing,et al.(1.Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310009,Zhejiang,China; 2.Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310012,Zhejiang,China)  
Objective To observe the effects of Radix Potentilla anserine and Ophiopogon japonicus extract on blood glucose. Methods Diabetic mice were randomly assigned into four groups of 10 mice.The mice in low dose group,medium dose group,and high dose group were administered intragastrically with extract 0.05 g/kg,0.10 g/kg,and 0.30 g/kg respectively, and the 10 mice in diabetes mellitus group were administered with distilled water once daily on 30 successive days.The levels of fasting blood glucose and blood glucose at 0,0.5 and 2 hours after glucose administration were determined.The alteration of area under the curve of blood glucose was observed after glucose administration.Result Fasting blood glucose in the mice of high dose group decreased significantly as compared with that of diabetic mellitus group(P0.05).Conclusion Radix Potentilla anserine and Ophiopogon japonicus extracts might decrease the level of fasting blood glucose.
【CateGory Index】: R285.5
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