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《The Journal of Practical Medicine》 2005-02
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The changes in apoptosis and Fas/FasL expression in newborn rats with lung injury by hypoxia

LU Hui, TAO Li, CHEN Ke zheng, WAN Gen ping. Children hospital,Guangzhou 510120,China  
Objectives To observe the expression of apoptosis related gene Fas/FasL on lung injury caused by hypoxia and inhaled 100%O2 after hypoxia. Methods Two lung injury rat models were established by hypoxia or inhaled 100%O2 respectively. Apoptosis of the lung tissue was observed with the methods of Tunel and in situ hybridization. mRNA expression of Fas/FasL was detected by SqRt PCR. Results Apoptosis of rat pulmonary alveolar epithelial cells and pneumoangiogram endothelial cells appeared after 4 hours in two groups. And the index of apoptosis increased with the time passing by (P=0.003, 0.005 respectively). And expression of Fas/FasL mRNA or proteins was up regulated in two groups, which in inhaled pure oxygen group was higher than in hypoxia group. Conclusions Apoptosis and upregulated Fas/FasL mRNA and its relatedproteins play an important role on lung injury which was caused by hypoxia or inhaled pure oxygen after hypoxia.
【Fund】: 广东省医学科研基金项目(项目编号:A2002597);; 广州医学院科研基金项目(项目编号:01-K-06)
【CateGory Index】: R363
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