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Change of platelet parameters and its clinical significance in neonates with cerebral damage

PU Xiu-hong,GUO Xiao-qing,QIU Meng,LI Qian,AN Tao. Department of Pediatrics,the 309th Clinical Division,General Hospital of the People′ s Liberation Army,Beijing 100091,China  
Objective To explore the change of platelet parameters and its clinical significance in neonates with cerebral damage. Methods 66 neonates with hypoxic-ischemic encephalopathy (HIE) or intracranial hemorrhage (ICH) were included in the study. Their platelet total (PLT),mean platelet volume (MPV) and platelet distribution width (PDW) were detected in the acute stage (under three days after birth) and recovery stage (seven days after birth). The data were compared with those from 30 cases of neonatal asphyxia without cerebral damage and 40 healthy neonates born in 3 days. The data from the neonates with ICH (n=24) were also compared with those from the neonates with HIE (n=42). 42 cases of HIE were then divided into three groups based on their clinical severity and the data from these three groups were similarly compared. Results (1)PLT in the neonates with cerebral damage during the acute stage was obviously lower than those in the neonatal asphyxia without cerebral damage and the healthy neonates (P 0.01) whereas MPV and PDW were obviously higher (P 0.01). There was no significantly difference of PLT,MPV and PDW among the neonates with cerebral damage during the recovery stage,the neonatal asphyxia without cerebral damage and the healthy neonate (P 0.05). (2)PLT in the neonates with ICH during the acute stage was markedly lower than that in the neonates with HIE (P 0.01) but MPV and PDW were obviously higher (P 0.01).( 3) PLT decreased with the severity of HIE (P 0.01 and P 0.05) while MPV and PDW increased with the severity of HIE (P 0.01 and P 0.05).Conclusion Dynamic observation of the platelet parameters can be of value to diagnose neonates with cerebral damage and to determine the severity of the damage and the platelet parameters may be used to predict the early intracranial hemorrhage
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