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《The Journal of Practical Medicine》 2007-22
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A study of the relationship between diabetes mellitus and colorectal cancer

WANG Rong-xin,HU Shui-qing.Emergency Department,Xuanwu Hospital,Capital Medical University,Beijing 100053,China  
Objective To explore the relationship between diabetes mellitus(DM)and colorectal cancer(CRC)and better understand the role of a history of DM in the oncogenesis of the malignancy.Methods A case-control study comparing the differences in prior history of DM,family history of DM,lifestyle such as smoking and alcohol intake,and serum levels of cholesterol and triglyceride between 364 patients with CRC who had been hospitalized and 733 non-cancer patients who had also been admitted was conducted to analyze the relationship between CRC and DM-related factors.Results The risk of developing CRC was 1.72-fold higher in diabetic patients than in those without DM and was also markedly elevated in the individuals who had a family history of DM,with an odds ratio of 1.64.The genesis of CRC was significantly affected by prior history of DM but not by age,sex,smoking,alcohol intake,family history of DM,coronary artery disease,hypertension,and serum lipid levels.Conclusion DM is correlated with the oncogenesis of CRC and increases the risk of developing CRC.
【CateGory Index】: R587.1;R735.3
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