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《The Journal of Practical Medicine》 2009-12
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Effects of oxymatrine on the expression of intercellular adhesion molecule-1 in experimental left atrial fibrosis in rabbits with atrial fibrillation

SONG Hui-wen, WANG Lin.Department of Cardiovasology, Baoan People's Hospital Affiliated to Southern Medical University, Shenzhen 518110, China  
Objective To study the effects of oxymatrine on the expression of intercellular adhesion molecule-1(ICAM-1) in experimental atrial fibrosis in rabbits with atrial fibrillation(AF) and to explore the mechanism of anti-myocardial fibrosis of oxymatrine.Methods Experimental myocardial fibrosis of rabbits with AF was built and treated by oxymatrine simultaneously.Serum levels of C-reactive protein(CRP), hyaluronate(HA), and laminin(LN) were measured, myocardial pathological changes was observed, and the expression of ICAM-1 in myocardial tissues was detected by immunohistochemistry.Results As compared with rabbits without oxymatrine treatment, serum levels of CRP, HA, and LN, the degrees of inflammatory activity and fibrogenesis, and the expression of ICAM-1 were decreased significantly in the oxymatrine-treated rabbits(P 0.05).Conclusion Down-regulation of the expression of ICAM-1 and myocardial inflammatory activity may be involved in the anti-fibrogenesis mechanisms of oxymatrine.
【CateGory Index】: R285
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