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《The Journal of Practical Medicine》 2012-05
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Research on the inhibitory effect of quercetin on the growth and proliferation in human colon carcinoma cell line SW480 in vitro

LIN Zeng-hai, MA Tao, MENG Yong. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China  
Objective To observe the inhibitory effect on the growth and proliferation of human colon carcinoma SW480 cell line in vitro induced by quercetin. Methods SW480 cells were incubated in vitro by cell biology technique. By means of CCK-8, the effect of quercetin on SW480 cell was studied, the morphological change of SW480 cell was investigated by light microscope and electron microscope. Flow cytometry using propidium iodide (PI) staining was used to determine the cell cycle and cell apoptotic rate. Results Quercetin inhibited the growth of SW480 cell by a time- and dose- dependent manner (P 0.05). The amount of SW480 cell treated by quercetin decreased. Apoptotic corpuscles were found by electron microscope. The apoptosis rate of SW480 cell was improved, and induced cell cycle arrest in G2/M in does-dependent manner of quercetin (P 0.05). Conclusion Quercetin can inhibit the growth of SW480 cell by a time- and dose- dependent manner and induce the apoptosis of SW480 cell in vitro.
【Fund】: 广东省科技计划项目(编号:2009B030801321);; 广东省中医药局科研课题(编号:2009232 2008164)
【CateGory Index】: R735.35
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【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 MENG Yong,LI Hua,LIN Zeng-hai,et al.Department of General Surgery,the First Affiliated Hospital of Medical School of Shantou University,Shantou 515041,Guangdong,China;Inhibitory Effect of Quercetin on Invasion of Colon Cancer Cell SW480[J];Chinese Journal of General Practice;2011-07
2 ZHANG Guoli1,TENG Hongli2,CHEN Keli1(1.Hubei University of Chinese Medicine,Wuhan 430065,China;2.Guangxi Institute of Traditional Minority Medicine,Nanning 530001,China);Advances in study on chemical constituents and pharmacological effects of Berchemiae Ramulus of the Traditional Zhuang Medicine[J];China Medical Herald;2011-06
3 MENG Yong,LI Hua,LIN Zeng-hai,WU Hua-tao,MA Tao.Department of General Surgery,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Effect of quercetin on matrix metalloproteinases and Cathepsin-D of the SW480 human colon cancer cell in vitro[J];Chinese Journal of Clinicians(Electronic Edition);2011-12
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