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《The Journal of Practical Medicine》 2014-06
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Changes of serum NUCB/nesfatin-1 levels in gestational diabetes mellitus

WU Xiao-yan;LI Rui;WU Li-qun;YE Cheng-cheng;LI Chai-wei;Wenzhou Hospital of Traditional Chinese and Western Medicine;  
Objective To investigate the relationship between serum nesfatin-1 and gestational diabetes mellitus(GDM). Methods The serum nesfatin-1 concentrations were measured in 45 GDM patients and 44 NGT pregnant women, as well as 47 non-pregnant healthy women served as control. Serum nesfatin-1 were measured by sandwich enzyme linked immunosorbent assay(ELISA). Meanwhile FPG、 lipoid、 FFA、 FINS、 C-tide were also measured. Result Serum nesfatin-1 level in GDM were significantly higher in GDM patients than in NGT and control(P0.01), while serum nesfatin-1 in NGT was significantly lower than in control(P0.01). Correlation analysis showed that serum nesfatin-1 was positively correlated with FINS, C-tide, HOMA-IR, triglycerides FBG and OGTT 1 hour glucose, HbA1c(P0.05). Conclusion Serum nesfatin-1 level in pregnant women significantly decreas, while in GDM patients significantly increase. Serum nesfatin-1 level in pregnant women is positively correlated with Insulin resistance(IR) and triglycerides level.
【Fund】: 温州市科技局基金(编号:Y20130074)
【CateGory Index】: R714.256
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHENG Qing,LI Guo-dong.Department of Laboratory,Haikou Municipal People′s Hospital,Haikou 570208,China;Effects of Exercise and Diet Intervention on Insulin Resistance and Serum Adiponectin and Visfatin Levels in Patients with Gestational Diabetes Mellitus[J];Chinese General Practice;2012-30
2 LIU Jiangling,LI Min The People's Hospital of Xixiang in Baoan District,Shenzhen City,Guangdong Province,Shenzhen 518102,China;The early stages of pregnancy built to prevent pregnancy mother-child care manual complications role[J];China Medical Herald;2011-15
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4 GUO Wei;GAO Mingsong;YE Zhenghua;LI Yang;TU Jiajun;LEI Weimin;Department of Endocrinology,the First Hospital of Wuhan;;Effects of metformin on the serum nesfatin-1 and liver steatosis in type 2 diabetic patients with nonalcoholic fatty liver disease[J];Chinese Journal of Difficult and Complicated Cases;2014-04
5 Zi-Bin Tian;Run-Jun Deng;Gui-Rong Sun;Liang-Zhou Wei;Xin-Juan Kong;Xue-Li Ding;Xue Jing;Cui-Ping Zhang;Yin-Lin Ge;Department of Gastroenterology,Affiliated Hospital of Medical College of Qingdao University;Clinical Laboratory,Affiliated Hospital of Medical College of Qingdao University;Department of Biochemistry and Molecular Biology,Medical College of Qingdao University;;Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats[J];世界胃肠病学杂志(英文版);2014-22
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 YUAN Lifang;CLINICAL ANALYSIS OF RISK FACTORS OF GESTATIONAL DIABETES MELLITUS[J];Modern Hospital;2008-06
2 YU Jian ,LIN Feng,ZHOU Su-xian,et al.Department of Endocrinology,The Affiliated Hospital,Guilin Medical College,GuiLin 541001,China.;The correlation of adiponectin level with insulin resistance in patients with gestational diabetes mellitus[J];Chinese Journal of Diabetes;2008-03
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