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《The Journal of Practical Medicine》 2014-06
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Changes of serum NUCB/nesfatin-1 levels in gestational diabetes mellitus

WU Xiao-yan;LI Rui;WU Li-qun;YE Cheng-cheng;LI Chai-wei;Wenzhou Hospital of Traditional Chinese and Western Medicine;  
Objective To investigate the relationship between serum nesfatin-1 and gestational diabetes mellitus(GDM). Methods The serum nesfatin-1 concentrations were measured in 45 GDM patients and 44 NGT pregnant women, as well as 47 non-pregnant healthy women served as control. Serum nesfatin-1 were measured by sandwich enzyme linked immunosorbent assay(ELISA). Meanwhile FPG、 lipoid、 FFA、 FINS、 C-tide were also measured. Result Serum nesfatin-1 level in GDM were significantly higher in GDM patients than in NGT and control(P0.01), while serum nesfatin-1 in NGT was significantly lower than in control(P0.01). Correlation analysis showed that serum nesfatin-1 was positively correlated with FINS, C-tide, HOMA-IR, triglycerides FBG and OGTT 1 hour glucose, HbA1c(P0.05). Conclusion Serum nesfatin-1 level in pregnant women significantly decreas, while in GDM patients significantly increase. Serum nesfatin-1 level in pregnant women is positively correlated with Insulin resistance(IR) and triglycerides level.
【Fund】: 温州市科技局基金(编号:Y20130074)
【CateGory Index】: R714.256
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