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《The Journal of Practical Medicine》 2014-23
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Effects of Qingfeitang on ET-1 and PGE_2 in exhaled breath condensate and serum of patients with ARDS

GU Yan;CHEN Jian-rong;SHAO Feng;GAO Xiang;TANG Yan-fen;XU Zhi-hua;LI Hong;Second Affiliated Hospital of Nantong University;  
Objective To observe the changes of endothelin-1(ET-1) and prostaglandin E2(PGE2) in exhaled breath condensate(EBC) and serum of patients with acute respiratory distress syndrome(ARDS) after treated by Qingfeitang and investigate its clinical value. Methods 52 ARDS patients receiving mechanical ventilation at intensive care unit(ICU) were divided into the Qingfeitang treatment group and the control group,with 26 cases in each group. The EBC were collected by Ecoscreen condenser within 24 h after diagnosis of ARDS and on the 5th day of medication, and the venous blood were collected at the same time. The levels of ET-1 and PGE2 in the EBC and serum of different period were measured by EIA. Results(1) After treatment, The levels of ET-1 in EBC and serum of the Qingfeitang treatment group were significantly lower than those of the control group.(2) After treatment, the levels of PGE2 in serum of the Qingfeitang treatment group were significantly lower than that of the control group.(3) The oxygenation index difference before and after treatment of Qingfeitang in the treatment group was higher than in the control group.(4) The duration of mechanical ventilation of the Qingfeitang treatment group was significantly less than that of the control group. Conclusions Qingfeitang could be an effective method for alleviating acute respiratory distress syndrome.
【Fund】: 江苏省中医药管理局科技项目(编号:LZ11157);; 2012年南通市第四期“226工程”培养对象科研项目
【CateGory Index】: R285.6
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