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《Journal of Practical Traditional Chinese Internal Medicine》 2011-07
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The Experiment Study on Gynostemma External Skin Tissue on the Natural Aging Mice,CAT Activity,MDA Content

WANG Cai-xia,WANG Li-xin(Ningxia Medical University,Yinchuan 750004,Ningxia,China)  
[Objective]To observe the gynostemma extract natural aging mice skin tissue catalase(CAT) activity and malondialdehyde(MDA) content,and to study different routes of administration of the natural aging mice skin improvement.[Method]3 month old female Kunming mice,10 rats as young control group(A);Kunming 40 female mice aged 12 months were randomly divided into 4 groups of 10 each: external control group aged(B),aged external positive control group(C),old external Gynostemma group(D),elderly(topical + oral) Gynostemma group(E).A,B group treated with excipient 0.5g / t,C group treated with vitamin E20mg / t,D group treated with Jiaogulan cream 0.5g / t,E group treated with Jiaogulan cream(the same dose of D),while ig Gynostemma extract 0.8mL / t.After 30 days determined by biochemical analysis of CAT activity in skin tissues,MDA,and to observe changes in the organizational structure of skin.[Results]A group,B,C,D,E groups of mice skin tissue CAT activity was significantly decreased(P0.01),MDA was significantly increased(P0.01);with the B group,C,D,CAT activity in group E increased(P0.05),MDA content decreased(P 0.01);with the D group,E group significantly increased CAT activity(P0.05),MDA content was decreased(P0.05).[Conclusion] Gynostemma extract skin of mice with the antagonistic effect of natural aging;external accompanied by intragastric administration of Gynostemma extract this kind of approach to better delaying the natural aging on skin damage.
【CateGory Index】: R285.5
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