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Exprssion of nm23H_1 and PCNA in gestational trophoblastic tumors and its clinical significance

XU Jian-yun,SHI Yi-fu (Affiliated Hospital of Gynecology and Obstetrics,College of Medical Sciences,Zhejiang University,Hangzhou,310006,China)  
Objective To evaluate the relationship between nm23H 1 expression levels and metastasis and proliferation of gestational trophoblastic tumors(GTTs) and to observe the influence of chemotherapy on proliferative status of GTTs.Methods Expression of nm23H 1 and PCNA was determined in 48 cases of gestational trophoblastic tumors,10 complete hydatidiform mole and 10 normal first trimester trophoblast with immunohistochemical methods.Results The results show that nm23H 1 expression was stronger in first trimeter trophoblasts and hydatidiform mole than that in GTTs( P 0.01).nm23H 1 expression in invasive hydatidiform mole was stronger than that in choriocarcinoma( P 0.05);it in those of WHO stage I,II was stronger than that in stage Ⅲ,Ⅳ;and WHO scoring non high risk group had stronger nm23H 1 expression than high risk group.GTTs have more PCNA positive trophoblastic cells than normal first trimester trophoblast( P 0.05).Conclusion nm23H 1 detection has referential value in evaluating metastasis potential and prognosis of GTTs.
【CateGory Index】: R737.33
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