Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Reproduction & Contraception》 1983-02
Add to Favorite Get Latest Update

EFFESTS OF GOSSYPOL ON THE IMPLANTATION OF FEMALE RATS AND ITS MECHANISM ANALYSIS

Yuan Qi-xiao (Department of Physiology,Beijing Medical College) Gao De-wei Li Chun-zhong (Department of Biology,Beijing Normal College)  
The effects of Gossypol acetic acid on implantation,ovary steroid-3β-ol-dehydro-genase activity and serum progesterone of female rats were observed.On Days 1-5 ofPregnancy of rats,the Gossypol acetic acid suspension was given at a dose level of 100 mg/kgorally daily,while the same amount of distilled water was given to the control animals.The animals were sacrificed on Day 10 of pregnancy.It was found that the Gossypol acetic acid could effectively inhibit the implantationin rats with a rate of 85.7% and decrease serum progesterone.If progesterone(5 mg)orhCG(50 IU)was injected S.C.simultaneously with the Gossypol,the inhibitory effectsof the Gossypol could no longer be observed.But,if LH-RH (20 μg)was injected insteadof progesterone or hCG,the anti-implantation effects of the Gossypol remained.It was observed that the Gossypol acetic acid could not inhibit the effects of estradiolinducing the implantation of blastocysts in delayed implantation in rats.Accordingly,it seems that the anti-implantation effects of the Gossypol might be dueto the blocking of the supporting effects of endogenous LH on corpus luteum.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 SU Jing-li,LU Ying;Mentor: RONG Xiang-lu,QU Jing-feng,HAN Jian(Guangzhou University of Traditional Chinese Medicine,Guangzhou,510120,China);Effects of Matrine on mice sperm activity[J];海峡药学;2007-09
2 SHAO Shi xiang,DONG Qing jie,GUO Xing,CUI Zi qiang,LI Yan(Dept.of Biotechnology and Chemical Eng.,Tianjin Institute of Technology,Tianjin 300191,China);Progress in gossypol and its derivatives as a procreate-resistant drug[J];天津理工学院学报;2002-01
3 Zheng Weihong, Duan Hong and Wang Naigong(Hubei Sanxia Medical College, Yichang 443003);Effects of gossypol acetic acid combined with 15-methyl PGF_(2α) methyl ester(PG05) on early pregnancy mice[J];西北药学杂志;2000-01
4 Zheng WeiHong(Department of Preclinical Medicine)Wang NaiGong(Chinese Academy of Medical Science Peking Union Medical college Institute of Materia Medica ,Beijing100050);Effect of Gossypol Acetic Acid combined with 15-Methyl PGF_(2α) Methyl Ester on Early Pregnancy in Mice[J];湖北三峡学院学报;1998-01
5 Y Chen, L Cao and ZP Gu (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031);EFFECT OF GOSSYPOL IN COMBINATION WITH MISOPROSTOL ON TERMINATION OF EARLY PREGNANCY IN RATS AND MICE[J];药学学报;1997-11
6 Yang Ren-zhu Chen Jun-cai (Department of Biology,Nanjing Normal University,Nanjing,210024) Shen Wei-gan Geng Jian-ping (Yangzhou Medical College,Yangzhou,225001);Study of Cytogenetic Effect on Offspring of Again Reproduction After Injection of Gossypol into the Uterus on Termination of Early Pregnancy in Rats[J];生殖与避孕;1993-01
7 HQ Lei and YX Xu(Department of Pharmacology , Xi' an Medical University , Xi' an 710061);EFFECTS OF GOSSYPOL ACETIC ACID ON THE MOTILITY OF RAT OVIDUCT SMOOTH MUSCLE[J];药学学报;1993-01
8 Yan Renzhu (Department of Biology,Nanjing Normal University)Wu Guopei Wang Wenghua Cai Ming (Nanjing Institute of Materia Medica);Effect of Early Prefnancy Termination of Gossypol Derivatives in the Uterus of Female Rats[J];南京师大学报(自然科学版);1992-04
9 YH Zheng, ZH Wu and L Fang (Department of Physiology, Jiangxi Medical College, Nanchang 330006);EFFECT OF GOSSYPOL ACETIC ACID ON hCG-STIMULATED PROGESTERONE PRODUCTION OF DISSOCIATED RAT LUTEAL CELLS[J];药学学报;1991-11
10 HQ Lei and YX Xu (DePartment of Pharmacology, Xian Medical University, Xian 710061);EFFECTS OF GO SSYPOL ACETIC ACID ONTRANSPORT AND DEVELOPMENT OF FERTILIZED EGGS IN RATS[J];药学学报;1990-08
【Citations】
Chinese Journal Full-text Database 2 Hits
1 SHI QIXIAN ZHANG YINGONG(Zhejiang People's Academy of Experimental Hygiene, Hangzhou);STUDIES ON ANTIFERTILITY EFFECT OF GOSSYPOL I.EFFECTS OF GOSSYPOL ON ANDROGEN-DEPENDENT ORGANS IN MICE AND RATS[J];动物学报;1980-04
2 Dai Rong-xi;Pang Shih-nee;Lin Xin-kai;Ke Yi-bao;Liu Zhen-lian;Dong Rong-hua Shanghai Institute of Cell Biology, Academia Sinica;A STUDY OF ANTIFERTILITY OF COTTONSEED[J];实验生物学报;1978-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Guopeng;Li Weiwei;Zou Bo;Hao Xuehong;Shanxi Institute of Crop Science of Academy of Agricultural Sciences;Shanxi Plant Protection and Quarantine Station;Shanxi Institute of Plant Protection;College of Life Science of Shenzhen University;;Research Progress on Agriculture Commonly Used Deratization Technique[J];农业技术与装备;2015-07
2 Guo Yongwang;Wang Deng;Shi Dazhao;National Agro-Tech Extension and Service Center;College of Agronomy and Biotechnology,China Agricultural University;;Rodent damages and the management of agricultural rodent pests in China[J];植物保护;2013-05
3 Shi Qixian Chen Wenying Yuan Yuying Ni Ya Li Kun Chen Zhanghui Zhong Cuiling Sang Guowei (Zhejiang Academy of Medical Sciences,Hangzhou 310013);THE PROGRESSES IN MALE REPRODUCTIVE PHYSIOLOGY RESEARCH—Review of Our Team Research Archives[J];中国科学基金;2010-05
4 Summarize by Wang Maoshan. Revise by Sang Guowei,The Re-search Insititute for Family Planning of Zhejiang Province Insititute of Medical Science,Hangzhou ,310013.;The Mechanism of Gossypol-induced Hypokalemia.[J];中国计划生育学杂志;2001-05
5 Ye Bai-kuan;Zhang Shi-fu Department of Histology and Embryology, Beijing College of Traditional Chinese Medicine Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of medical Sciences, Beijing;Study on Effects of Gossypol on Incorporation of ~3H-Arginine in Pachytene Spermatocytes of Rat Testis by Cell Separation Technique of Elutriation[J];生殖与避孕;1991-02
6 Fang Lian,Wu Zhong-hua,Zhuang Wen-hua,Xu Si-fan (Department of Physiology,Jiangxi Medical College,Nanchang);EFFECT OF GOSSYPOL ACETATE ON THE TESTICULAR HCG REACTIVITY AND IT'S RECEPTOR IN THE RATS[J];实验生物学报;1988-03
7 Zhang Shifu, Zhang Jingbo and Yuan Ju (Institute of Basic Medical Sciences, Beijing);Synergic Effects of Gossypol Acetate and Sulphadiazine on LDH-x activity and Viability of Human Sperms[J];中国医学科学院学报;1985-03
8 ZHANG JING-BO YANG YU-ZHOU YUAN JU AND XUE SHER-PU (Department of Cell Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing);OBSERVATIONS OF IN VITRO FERTILIZATION CAPACITY AND THE TRANSFORMATION OF HUMAN SPERM NUCLEI BEFORE AND AFTER ADMINISTRATION OF GOSSYPOL ACETIC ACID[J];实验生物学报;1985-01
9 Li Fengyuan Wang Naigong and Lei Haipeng(Institute of Materia Medica, Beijing);Antiandrogen Effect of Gossypol and Its influence on Androgen Receptor[J];中国医学科学院学报;1985-01
10 Qiu Shu-dong;Guo Ren-yu Department of Histology and Embryology, Xian Medical College;RESPONSE OF INTERSTITIAL CELLS TO hCG IN PREPUBERTAL RAT TESTES FOLLOWING ADMINISTRATION OF GOSSYPOL[J];生殖与避孕;1984-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SUN Xiao-mei,CHEN Yu,LI Chun-hua,PENG Hui,LIN Shan-liang,DAI Jie-jie(Institute of Medical Biology,Chinese Academy of Medical Science,Kunming 650118,China);Study on Establishment of Oligozoospermia Animal Model in Cynomolgus monkey[J];实验动物科学与管理;2006-02
2 ZHANG Hong-li,YANG Qing-er, YANG Xue-jun,WANG Ming-chun,BU Shu-hai,HAN Chong-xuan~*(College of Forestry,NW Sci-Tech University of Agriculture and Forestry,Yangling,shaanxi,China 712100,China);Matrine Extraction and Isolation, and Toxicity to Mus musculus[J];西北植物学报;2005-08
3 YUAN Jing 1,2,LU Liang-Zhong2,CONG Bin1,ZHANG Zong-Jian2,WANG Feng-Yu2 (1Shenyang Agriculture University,Shenyang 110161,China; 2Shenyang Research Institute of Chemistry Industry,Shenyang 110021,China);Biological Activity of Alkaloids from Sophora flavescens Ait to Pests[J];农药;2004-06
4 Luo Xudong,Fang Zhiping, Tian Hanwen (Department of Pharmacology,West China Medical Center of Sichuan University,Chengdu 610041);Study on the effect of cimetidine on anti-middle-pregnancy[J];四川生理科学杂志;2004-01
5 QIAN Xiao_wei (Department of Life and Environmental Science,Wenzhou Normal College, Zhejiang Wenzhou 325003 PRC);The Mutagenic Effects of Traffic Pollutant on the Mice in Wenzhou City[J];江西科学;2004-01
6 GANYa-ping 1 ,ZhAO Hong-gang 1 ,DIAO Lu-ming 2 ,LI Cai-rong 1 (1.Dept.of Pathology,Xianning Medical College,Hubei Xianning437100;2.Dept.of Pathology Medical College,Wuhan University,Wuhan430070,China);Study on Effects of Kuaishaling on Sperm Toxicity in Mice[J];环境与职业医学;2003-06
7 LIU Mei, LIU Xue-ying, CHENG Jian-feng (TangDu Hospital, the Forth Military University, Xi'an 710038, Shaanxi, Chi na);Advance in the Pharmacological Research on Matrine[J];中国中药杂志;2003-09
8 YU Hong-yu,TANG Xun,NIE Li-bo,YU Kai-lu(College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China);The Issues on Exploitation and Application of Gossypol[J];山东化工;2000-04
9 Zheng Yongquan Yao Jianren Shao Xiangdong(Institute of Plant Protection, Chinese Academy of Agricultural Sciences 100094);Review on the Constituents and Agricultural Application of Sophora flavescens Ait.[J];农药科学与管理;2000-01
10 B Yang, L Cao, Y Xu, ZX Sun and ZP Gu (Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 200031);THE EFFECTS OF GOSSYPOL ON RAT LUTEAL CELLS, HUMAN DECIDUAL CELLS AND CYTOTROPHOBLASTS[J];药学学报;1997-08
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WU Jin-yang;ZHANG Shu-feng;MENG Xin;Huabei University of Science and Engineering;Chengde Medical College;;Studies on the Influences of TCM to Reproduction Toxicity[J];河北北方学院学报(自然科学版);2015-06
2 WANG Ya;BI Yanlan;College of Food Science and Technology,Henan University of Technology;;Optimization of extraction of gossypol in single solvent system by response surface methodology[J];中国油脂;2015-08
3 Xie Gui-yuan;Guan Lan;Liu Xin-ming;Wang An;School of Public Health, Central South University;;Mutagenicity Study on 3% matrine agent[J];湖南师范大学学报(医学版);2015-01
4 CHAI Xiuhang;FU Yuanyuan;BI Yanlan;YANG Guolong;SUN Shangde;LIU Wei;School of Food Science and Technology,Henan University of Technology;;Optimization of extraction of free gossypol from cottonseed kernel[J];中国油脂;2014-05
5 WANG Jing;YAO Jun;XUE Hai-yan;ZHANG Huang-tao;WU Yun;College of Food Science and Pharmacy, Xinjiang Agricultural University;College of Pharmacy, Xinjiang Medical University;Xinjiang ProvincialSupervising and Testing Research Institute for Products Quality;;Determination of gossypol in cottonseed, cotton leaves and cotton stalk by LC-MS with internal standard method[J];食品科技;2013-11
6 ZhangYan,Zhang Chunying~*,JiangJun Department of Urology No2,The Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China;Experimental study of the effect of Matrine on the spermatozoa membrane lipid fluidity in male rats[J];中国男科学杂志;2011-12
7 Liang Xiaowei, Lu Wenhong, Gu Yiqun, Li Hong, Wu Zhigang, Chen Zhenwen National Research Institute for Family Planning, Beijing 100081;Antifertility effect of low-dose gossypol acetate in Chinese men[J];中国计划生育学杂志;2011-12
8 ZHU Shi-fa,TANG Hui,ZHAO Wen-bing(College of Pharmacy,Shihezi University,Shihezi,Xinjiang 832002,China);Triazole and gossypol's derivatives synthesis and research on antibacterial activity[J];现代医药卫生;2011-02
9 Zhu Shifa,Tang Hui,Zhao Wenbing(College of Pharmacy Shihezi University Shihezi XinJiang 832002 China);Synthesis of Sulfanilamide and Gossypol's Derivatives[J];北方药学;2011-01
10 Yang Chong Wang Chengming(College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070);Ultrasonic Wave-Assisted Extraction of Gossypol from Cottonseed Meals[J];中国粮油学报;2011-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Dai Rong-xi;Pang Shih-nee;Lin Xin-kai;Ke Yi-bao;Liu Zhen-lian;Dong Rong-hua Shanghai Institute of Cell Biology, Academia Sinica;A STUDY OF ANTIFERTILITY OF COTTONSEED[J];实验生物学报;1978-01
Similar Journals
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved