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《Reproduction & Contraception》 1986-04
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EFFECTS OF SINGLE INJECTION OF GOSSYPOL ACETATE INTO THE UTERUS ON IMPLANTATION IN RAT AND ANALYSIS OF ITS MECHANISM

Yang Ren-zhu Zhang Yan-hong Qu A-xiang (Department of Biology,Nanjing Normal University)  
This experiment was carried out on the fourth day of pregnancy of 14 rats,0.5 mg ofgossypol acetic acid in 0.1 ml suspension was injected into one uterine horn and sameamount of solvent was given to the other horn as control.The animals were sacrificed onthe 12 th day of pregnancy and differences between the two horns were observed carefully.It was found that a single injection of a small dosage of gossypol acetic acid produced an an-tifertility rate of 100% and an antiimplantation rate of 71% in the experimental horn ofrat.But there was no difference in the activity of △~5-3β-hydroxysteroid-dehydrogenasein the two ovaries.The effect of a single injection of small dosage of gossypol acetic acid into one horn ofthe rat uterus with pseudopregnancy was also studied.The results showed that the injec-tion could obviously inhibit the hyper-decidual changes of the pseudopregnant uterus of rat.This may be one of the mechanism of antifertility action of gossypol.
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