Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

The Effect of Mifepristone Compound on Esrtrogen and Progestrone Receptors of Early Pregnancy in Decidua

JIN Li, SHEN Wei xiong *, SUN Zhi da *, FAN Guang sheng, WU Yu ming, WANG Han zheng (Department of Obstetric and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, CAMS, Beijing, 100730) ( * Shanghai Institu  
WT5BZ] The effect of mifepristone compound on estrogen and progesterone receptors in decidua was studied. Sixty normal early pregnant volunteers(≤49 d)were randomly allocated into 6 groups,10 in each group. Group A:control group; Group B and Group C were administrated mifepristone 40 mg and 75 mg orally respectively, once per day, for two days; Group D(Group 4∶1): given mifepristone compound 1 tablet orally (mifepristone 20 mg+AF 53 5 mg)a day, for two days; Group E(Group 6∶1): given mifepristone compound 1 tablet(mifepristone 30 mg + AF 53 5 mg)a day, for two days; Group F(Group 8∶1): mifepristone compound 1 tablet(mifepristone 40 mg + AF 53 5 mg), at the same closeage above; concentration of ER and PR was measured by radio ligand assay in decidua tissue which were obstained after 48 h when mifepristone or mifepristone compound was administrated. Mifepristone compound in different doses significantly decreased the content of PR and increased ER and changed the balance of ER/PR. Among groups of mifepristone compound, Group E could also increased the concentration of EcR, which might be in favour of the endometrium recovery and shorten the bleeding days after abortion.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved