The Effect of Mifepristone Compound on Esrtrogen and Progestrone Receptors of Early Pregnancy in Decidua
JIN Li, SHEN Wei xiong *, SUN Zhi da *, FAN Guang sheng, WU Yu ming, WANG Han zheng (Department of Obstetric and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, CAMS, Beijing, 100730) ( * Shanghai Institu
WT5BZ] The effect of mifepristone compound on estrogen and progesterone receptors in decidua was studied. Sixty normal early pregnant volunteers(≤49 d)were randomly allocated into 6 groups,10 in each group. Group A:control group; Group B and Group C were administrated mifepristone 40 mg and 75 mg orally respectively, once per day, for two days; Group D(Group 4∶1): given mifepristone compound 1 tablet orally (mifepristone 20 mg+AF 53 5 mg)a day, for two days; Group E(Group 6∶1): given mifepristone compound 1 tablet(mifepristone 30 mg + AF 53 5 mg)a day, for two days; Group F(Group 8∶1): mifepristone compound 1 tablet(mifepristone 40 mg + AF 53 5 mg), at the same closeage above; concentration of ER and PR was measured by radio ligand assay in decidua tissue which were obstained after 48 h when mifepristone or mifepristone compound was administrated. Mifepristone compound in different doses significantly decreased the content of PR and increased ER and changed the balance of ER/PR. Among groups of mifepristone compound, Group E could also increased the concentration of EcR, which might be in favour of the endometrium recovery and shorten the bleeding days after abortion.