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《REPRODUCTION AND CONTRACEPTION》 1996-04
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The Effct of Norethisterone on Progesterone and Estrogen Receptor Concentration in Human Decidua on Early Pregnancy

Zhang Jun-hui; Zhou Jian-ping; Lu Xiang-yun;Lu Hui-juan; Wang Jin (Institute of Gynecological and Obstetrical Hospital,Shanghai Medical University, Shanghai, 200011)  
Decidual concentrations and binding sites of progesterone receptor(PR)and estrogen recepor (ER)were measured with dextran coated absorption (DCC) and cytochemical method. 27 women were randomly divided into control and experimental groups. Pregnancies were terminated by vacuum aspiration on 6th day after norethisterone use(5mg, 3 times daily ×5days). It was observed that norethisterone significantly decreased decidual cytosol ER content (P0. 05). It seems that the down-regulation of decidual ER by norethisterone may be one of causes of anti-early pregnancy.
【Key Words】: Norethisterone Estrogen receptor Progesterone receptor Decidua
【Fund】: 上海市科学发展基金
【CateGory Index】: R979.21
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【Co-references】
Chinese Journal Full-text Database 10 Hits
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