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《REPRODUCTION AND CONTRACEPTION》 1996-05
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Effects of Mifepristone on Glycosphingolipids and Estrogen and Progesterone Receptors from Human Decidua and Villi

Zhou Jian-ping; Zhang Jun-hui; Liu Yin-kun;Sun Cui-xiang; Lu Xiang-yun(Obs & Gyn Hospital,Shanghai Medical University,Shanghai, 200011 )(Zhong Shan Hospital,Shanghai University,Shanghai, 200032)  
Effects of mifepristone on glycosphingolipids and hormone receptors from human decidua and villi were studied to investigate the mechanism of terminating pregnancy. By using the Ladisch partition methods,Sephadex G-25 chromatography and quantitative densitometric technique,alteration of the amount and composition of glycosphingolipids from decidua and villi was found under effects of mifepristone. Increasing estradiol receptors and declining progesterone receptors were measured from mifepristone affected decidua. These evidences indicated that roles of mifepristone against early pregnancy were wide and mainly direct through decidua.
【Key Words】： Mifepristone Glycosphingolipids Hormone receptor Decidua Villi
【CateGory Index】： R979.22
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