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《CHINESE JOURNAL OF NEPHROLOGY, DIALYSIS & TRANSPLANTATION》 1995-01
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Clinical effects of Rheum and captopril onpreventing progression of chronic renalfailure

Yu Yusheng ;Li Leishi ;Zhang Xu(Deparrment of Nephrology, Jinling Hospi-tal , Nanjing, 210002)  
clinical trial was carried out to evalu-late the effects of a Chinese herbal drug, Rheum E and ACEI captopril on chronic re-nal failure (CRF). 150 cases with initialserum creatinine (Scr) level 274. 6±96. 4μmol/L were allocated randomly to 3groups : Rheum E treated group(6. 2±2. 4g/d) , captopril treated group (54±22mg/d) and Rheum E(6. 2±2.1g/d) plus capto-pril ( 58±20mg/d) group. During the 15~62 months of treatment, all patients werekept on low protein(0. 6g · kg-1/d) and lowphosphorus (10mg · kg-1/d) diet. The re-sults showed that the Scr level and bloodurea nitrogen were kept stable or fell slight-ly. Albumin rose during the follow-up peri-od (P0. 05) in both Rhume E and RheumE plus captopril groups. It was also showedthat the progression rate of renal failure,calculated by regression of 1/Scr vs time re-tarded markedly in both Rheum plus capto-pril and Rheum groups as compared withcaptopril group. Uremic symptoms of nau-sea ,anorexia improved in most of the treat-ed patients. It is concluded that long-termand low-dose Rheum E taken orally is bene-ficial to CRF. Its effect is better than that ofcaptopril. The regime of Rheum E and cap-topril is a preferable choice in the long-termtreatment for preventing progression ofCRF.
【CateGory Index】: R285.6
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