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《CHINESE JOURNAL OF NEPHROLOGY, DIALYSIS & TRANSPLANTATION》 1996-05
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Clinical significance of blood endothelin and nitric oxide in patients with chronic renal failure

Jin Xiaohong, Wang Xiaojin, Liu Chuiling, Su Hongyue Department of Internal Medicine and Central Laboratory, Second affiliated hospital, Nanjing Medical University(Nanjing,210000)  
Endothelin(ET) is a very potent vasoconstrictor which can obviously reduce renal blood flow and glomerular filtration rate(GFR) by interacting with ET receptors. Nitric oxide(NO) is a strong vasorelaxing factor which modulates renal blood flow(RBF), GFR and tubular sodium bsorption. The balance of ET and NO influences renal hemodynamics. Twenty nine patients with chronic renal failure(CRF) were enrolled in this study, and 25 health adult set as control. CRF patients were divided into 3 subgroups according to their serum creatinine levels. Plasma ET was measured by radioimmunoassay and serum NO determined by the assay of chromium reduction. RESULTS 〖WTBZ] Plasma ET was significantly elevated in CRF patients(123.3±59.4 BHDW) as compared to the normal control(50.8±7.6BHDW)( P 0.05). It was positively correlated with the degree of renal function impairment and the severity of hypertension. Serum NO was also elevated in CRF patients(84.6±62.6BHDW) as compared to the control(52±13BHDW). No difference was found in serum NO between CRF subgroups with different degrees of renal function impairment. Elevated blood ET and No levels are observed in CRF patients, these changes may be related to the decrement of renal filtration.
【CateGory Index】: R692.5
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