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《Journal of Shenzhen University Science and Engineering》 2013-04
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Advance reseach on strategies for the prevention of Alzheimer's disease

Ni Jiazuan,Chen Ping,Liu Qiong,Zheng Yizhi,He Xiaoyang, Song Guoli,Ying Ming,and Xu Xu College of Life Sciences,Shenzhen Key Laboratory of Marine Biotechnology and Ecology, Shenzhen Key Laboratory of Microbial Genetic Engineering,Shenzhen University,Shenzhen 518060,P.R.China  
This review briefly introduces multiple theories on Alzheimer's disease(AD) pathogenesis such as the cholinergic theory,the amyloid-β cascade hypothesis,the ABC theory(aging,β-amyloid,channel),and theories of tau hyperphosphorylation,oxidative stress,neuronal apoptosis,and gene mutation.As AD is closely related with aging,and its pathology is caused by multiple factors,its pathogenesis is bound to be multiple and intricate.Besides,the loss of neurons cannot be regenerated,which suggests that early prediction and intervention in AD treatment is very important.This paper stresses the urgency in developing early diagnosis methods,including positron emission tomography(PET),magnetic resonance imaging(MRI),and sensitive AD biomarkers from blood and urine.The drugs for AD prevention and treatment are generally divided into six types: first-line drugs,vaccines,drugs in the research stage,adjuvant therapy drugs,traditional Chinese medicines,and health products(also known as Medical food).As the top three types have not yet make a breakthrough in AD treatment over a long period of time,people recently turned to pay close attention to the application and mechanism of the other three types of drugs for delaying AD progression.Research in our lab focuses on the effect and mechanism of the latter three types of drugs,and preliminary results show that selenomethionine,coenzyme Q-10,and icariin can significantly prevent AD progression.This paper evaluates the situation and challenge the anti-AD drugs are facing and proposes a change in the strategy for AD prevention: Single-target treatments should be abandoned,and multiple-target idea and inter-related systematic biology should be adopted for studying AD mechanisms and developing new drugs.
【Fund】: 国家自然科学基金资助项目(21271131 31070731)~~
【CateGory Index】: R749.16
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Chinese Journal Full-text Database 1 Hits
1 Wang Junxia;Liu Qingxin;Xiao Xinxing;Department of Neurology,the Affiliated Hospital of Binzhou Medical College;;The relationship between serum uric acid level and Alzheimer's disease[J];Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition);2014-03
Chinese Journal Full-text Database 10 Hits
1 Xu Yi~(1) Tian Jinzhou~(1) Sheng Shuli~(2) Shi Jing~(1) Ji Zhijuan~(2) Yin Junxiang~(1) Zhao Zhiwei~(2)(~(1)Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100700;~(2)Beijing Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053);Effect of GETO on Learning and Memory of Experiment AD Model Rats and Its Mechanism[J];China Journal of Traditional Chinese Medicine and Pharmacy;2006-04
2 YU Qi1,CUI Meng1,LI Yuan-bai2,YIN Ai-ning2(1Institute of Information on TCM,China Academy of Chinese Medical Sciences,Beijing 100700,China;2Data Center on TCM of Institute of Information on TCM,China Academy of Chinese Medical Sciences,Beijing 100700,China);literature appraisement of clinical trials in TCM treatment of Alzheimer's disease[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-04
3 WANG Haifeng , HUANG Jianzheng Department of Neurology, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;The clinical progress of PET/SPECT receptor imaging of Alzheimer' s disease[J];Chinese Journal of Neuromedicine;2003-06
4 FAN Ying1,2,YANG Zhao3,GENG Mei-yu1 (1.Department of Pharmacology,Marine Drug and Food Institute,Ocean University of China,Qingdao 266003,China;2.Department of Pharmacy,Qingdao The First Sanatorium of Jinan Command,Qingdao 266071,China;3.Qindao Institute for Drug Control,Qingdao 266071,China);Protective effect of alginate polysaccharide JM on brain ischemia injury in rats[J];Chinese Journal of Marine Drugs;2007-01
5 Xiang Zhiqing,Chen Yuemin,Xu Yifeng.Department of psychiatry,Huashan Hospital,Fudan University.Shanghai 200040;Pupil dilation test: a predictive test for Alzheimer's disease[J];Shanghai Archives of Psychiatry;2008-02
6 YAO Shulin, GUO Zhe, YIN Dayi, ZHANG Jinming, WANG Ruimin, TIAN Jiahe Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853, China;Role of (11)~C-PIB PET Imaging in the Evaluation of Alzheimer's Disease Rat Model[J];Science & Technology Review;2008-08
7 CHEN Chuan-feng,HE Cheng-lin,CHEN Hong-xia,SUN Ya-fei,PAN Xin(Department of Psychology,Ningbo University,Ningbo 315211,China);A Summary of Dementia Studies in China[J];Journal of Ningbo University(Educational Science Edition);2012-02
8 YAO Zhi-Wen1,3,DING Zheng-Tong1,WANG Jian1,JIANG Yu-Ping1,GUAN Yi-hui3 1Department of Neurology,2PET Center,Huashan Hospital,Fudan University,Shanghai 200040;3Department of Neurology,the 2nd Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;[~(11)C]6-OH-BTA-1's Biodistribution In Vivo Distribution of APP Transgenic Mice and Healthy Rhesus Monkey[J];Chinese Journal of Clinical Neurosciences;2009-04
9 SUN Li-Ping, XUE Chang-Hu, XU Jia-Chao, LI Zhao-Jie, CAI Yue-Piao, ZHAO Xue(College of Fishery, Ocean University of China, Qingdao 266003, China);A Study of the Antioxidant Abilities of Alginate Oligosaccharides[J];Journal of Ocean University of Qingdao;2005-05
10 ZHANG Weiwei~1,ZHANG Zhiguang~1,FENG Shuli~2,WANG Liang~2,YU Chunshui~2,LI Kuncheng~2(1.Department of Biomedical Engineering,Tsinghua University,Beijing 100084,China;2.Department of Radiology,Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053,China);Brain DT-MRI for recognition of Alzheimer's disease[J];Journal of Tsinghua University(Science and Technology);2005-12
China Proceedings of conference Full-text Database 1 Hits
1 Chen Ting,XU Li-li,CHEN Xiao-jing,HUANG Long-shen(Department of Statistics,Zhe Jiang Agriculture and Forestry University,HangZhou 31130,China);The Analysis and Forecast on Population Aging in China[A];[C];2011
Chinese Journal Full-text Database 10 Hits
1 ZENG Hong-bing,ZHOU Zhi-kun, WANG Xu-yuan(Guangzhou University of Traditional Chinese Medicine,Guangdong Guangzhou 510405, China);Effect of Huangqi Sanxian Recipe on Neurogliocytes in Ovariectomized Rat’s Brain[J];Journal of Anhui Traditional Chinese Medical College;2005-02
2 XIE Xiang-lin1,ZOU Hong-Bin2,LI Ye3,LIU Kai1,LIU Hong-yan1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Department of Nephrology,First Hospital,Jilin University,Changchun 130021,China;3.Department of Pharmaceutical Preparation,Port Hospital of Qin Huang Dao Port Group CO LTD,Qinhuangdao 066002,China);Effect of donepezil hydrochloride on learning and memory function of normal under age rats[J];Journal of Jilin University(Medicine Edition);2009-05
3 LV Gao-ping(Department of Neurology,Affiliated Hospital of Guilin Medical College,Guilin 541001,China);Research advance on early diagnosis of Alzheimer's disease by Western and Chinese medicine[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-08
4 HAO Hong RUAN Yao (Nanyang Higher Medical College,Nanyang 473000,China);Evaluation of Eclipta Prostrate on Activities of Tissue ATPase,Cellular Form and Memory Behavior on Aging Mice[J];Journal of Chengdu University of Traditional Chinese Medicine;2007-01
5 ZHAO Dan,WANG Qiu-kuan,ZHANG Hui-yi,LIU Yuan-ping,ZHANG Lin-lin(The Key Laboratory of Fishery Product Processing and Utilization of Liaoning Province,Dalian Ocean University,Dalian 116023,China);Moisture Absorption , Moisture Retention and Anti-oxidantive Activity of Crude Extract of Kelp (Laminaria japonica) and Sodium Alginate[J];Fisheries Science;2012-06
6 XU Lei,LI Zhan,ZHOU Huo-lan,DING Yu-ting,LIU Lin(College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China);Study of hygroscopic and moisturizing performance of oligosaccharides obtained from enzymolysis of algin[J];China Surfactant Detergent & Cosmetics;2011-01
7 LI Wen-de~* HUANG Ren WU Yu-e WANG Yuan-zhan MIN Fan-gui WANG Ke-wan. *Department of Pharmacology,Guangdong Medical College,Zhanjiang 524023,China;Effect on working memory by intracranial co-infusion of Aβ_(1-42) and thiorphan to establish AD model in Macaca Rhesus[J];Chinese Journal of Neuromedicine;2006-08
8 SONG Min~(1),TANG Jun~(2),LI Da-bing~(2),XU Hai-wei~(2),BAI Yun~(1)(~(1)Department of Molecular Genetics,~(2)Department of Physiology,College of Medicine,Third Military Medical University,Chongqing 400038,China);Genetype identification and histologic analysis of PS1/APP double transgenic Alzheimer disease mouse model[J];Acta Academiae Medicinae Militaris Tertiae;2006-14
9 GE Zhen-ying, SHI Chun, XU Xiao-wu, GUO Kai-hua, XU Jie. Department of biochemistry, the School of Medicine, Henan University, Kaifeng 475000 China;The observation of mitochondrial ultrastructure of neurons in the hippocampus and the basal forebrain of the estrogen with drawing rats[J];Anatomy Research;2006-02
10 Wu Dong, Yang Faming, Fan Gaiying, et al;To Study the Effects of Rhodiola Herb Against Behavior of Vascular Dementia Rat Lnduced by Chonic Cerebral[J];Guangming Journal of Chinese Medicine;2008-06
Chinese Journal Full-text Database 10 Hits
1 YAN Jing-lai,CHEN Yan-qing(Shanxi College of TCM,Taiyuan 030024,China);Traditional Chinese medical understanding on pathogenesis of senile dementia[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-07
2 LI Ying-dong1,2,ZHAO Xin-ke2,LIU Kai2(1Affiliated Hospital of Gansu College of TCM,Lanzhou 730000,China;2Department of Traditional and Western Medicine,Gansu College of TCM,Lanzhou 730000,China);Effect of ultra-filtration extract mixture from Angelica and Hedysari,radix on SOD,MDA,LDH1 and HSP70 in acute myocardial infarction rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-10
3 LV Gao-ping(Department of Neurology,Affiliated Hospital of Guilin Medical College,Guilin 541001,China);Research advance on early diagnosis of Alzheimer's disease by Western and Chinese medicine[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-08
4 LI Tuo,ZHAO Zhong-xin Department of Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;β-amyloid and Alzheimer disease:recent progress[J];Academic Journal of Second Military Medical University;2010-10
5 ZHENG Yan Song, LI Yuan, ZHANG Shan Hong, GONG Wei Qin, SUN Bin Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Experimental model of H_2O_2-induced oxidative injury in cardiomyocytes[J];Journal of The Fourth Military Medical University;2001-20
6 GAO Xu-hong,ZHAO Hai-hua,LAI Hong,TANG Zhong-yan,JIANG Wei,LI Xiu-ming.Department of Anatomy,Basic Medical College,China Medical University,Shenyang 110001,China;elationship between the Akt phosphorylation and caspase 3 expression in hippocampal formation of AD model rats[J];Anatomy Research;2011-06
7 SHI Hong-min1,WEI Sheng2 (1.Pharmacy Department,Deqing People′s Hospital,Deqing 313216,Zhejiang Province,China;2.Department of Pharmacy,Nanjing Drum Tower Hospital 210008,Nanjing,China);Protective effect of α-lipoic acid injection on H_2O_2 injury in PC12 cell[J];The Chinese Journal of Clinical Pharmacology;2011-06
8 YANG Xiao-hu,GUO Yan-sheng,QU Ya-ling,HUA Yong-li,DU Tian-xi,YANG Hong-shen,WEI Yan-ming(College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China);Study on free radical scavenging activities of water extract from Hedysarum polybotrys and Astragalus membranaceus in vitro[J];Journal of Gansu Agricultural University;2010-04
9 Liu Ye,Li Yingdong(Gansu College of TCM,Lanzhou 730000,China);Effects of serum containing gradocol membranes extract from Angelica Sinensis and Radix Hedysari on superoxide dismutase and oxyproline hydroxyproline of radiation cardiac fibroblasts[J];Journal of Gansu College of Traditional Chinese Medicine;2010-03
10 FU Jian-liang, SHAO Fu-yuan (1.Department of Neurology, 6th People's Hospital, Shanghai Jiaotong University; 2.Department of Neurology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China);Progress of pathogenesis of Alzheimer's disease[J];World Clinical Drugs;2010-07
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 NING Yu,LI Bo,FANG Fang,et al;Advance research on population aging and elderly population health and disease problems[J];Journal of Jilin University(Medicine Edition);2008-06
2 SHI Lin1,LIU Tian2(1.Mathematics,Physics and Biological Engineering School,Inner Mongolia University of Science and Technology,Baotou 014010,China;2.Ecounomics and Management School,Inner Mongolia University of Science and Technology,Baotou 014010,China);The prediction and analysis of China population ageing[J];Journal of Inner Mongolia University of Science and Technology;2010-04
3 Zhang Xiaojie1,2 Niu Yingcai1 Xing Guihua1 Lin Chunrong1 Li Xueyan1 Li Pengtao2 (1 Institute of Pharmaceutical Research,Qiqihaer College of Traditional Chinese Medicine,Qiqihaer,161042;2 Basic Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100029);Effect of Tongluo Jiunao Oral Solution on Learning and Memory and the Expression of AChE in Hippocampus of AD Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-06
4 XU Zhi, WU Guo ming, QIAN Gui sheng, WANG Shi wen, XUE Qiao (Institute of Respiratory Diseases of PLA, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China);Preliminary establishment of aging model in rat[J];Acta Academiae Medicinae Militaris Tertiae;2003-04
5 Chen Bin,Luo Weiwu,Chen Liling,Shi Guangqi,Chen Yiping,Li Ling'en,Lin Yongchao,Weng Saizheng,Deng Junqi,Chen Ming.Department of clinical psychology,Fuzhou Prevention and Cure Hospital for Neuropathy and Psychosis,Fuzhou 350008,China.;Condition of senile dementia and analysis of its dangerous social-psychological factors[J];Fujian Medical Journal;2009-01
6 Yuan Xianglin, Zhang Yukui , Zou Hanfa (Dalian Institute of Chemical Physics, National Chromatographic Research & Analysis Center, Chinese Academy of Sciences, Dalian 116011);Quantitative Analysis of Ginsenoside Rg_3 Using Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry[J];Chinese Journal of Analytieal Chemistry;2001-01
7 CHENG Liping, WANG Hong (Food College of South China Agriculture University, Guangzhou 510652, China);Research on Relationship of Chemical Structure and Bioactivity about Sulfate Polysaccharides[J];Guang Zhou Chemical Industry and Technology;2005-05
8 LV Lihua,CHEN Yanhao,WANG Li.Wuhan Mental Health Center,Wuhan 430030,China;The study on the blood fat levels and risk factors about vascular diseases in Alzheimer disease and vascular dementia[J];Hebei Medical Journal;2011-01
9 Zhang Baiqin Gao Xiaocheng(Heihe University) Yao Huanmin(Harbin Normal University);ANALYSIS AND FORECAST OF CHINA'S POPULATION AGING[J];Natural Science Journal of Harbin Normal University;2009-03
10 HAN Lijun YUAN Zhaohui FAN Xiao WANG JianInstitute of Oceanology, The Chinese Academy of Sciences, Qingdao 266071;A Review of Separation and Structure Determination Methods for Oligosaccharides[J];Studia Marina Sinica;2004-00
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