Clinical Observation of Treating Gastroenteric Carinoma with the Combinated Chemotherapy with Hydroxycamptothecin
XU Xin-qian, XIAO Ji-ping, ZHANG Li, LIU Da-wen(The First Hospital of Huangshi, Huangshi, Hubei 435001, China)
Objective:To study the efficacy and toxicity in combination chemotherapy with hydroxycamptothecin(HCPT) in advanced gastroenteric carinoma.Methods:86 patients were randomly devided into two groups: the treatment group received a combined therapy of cisplatin, leucorin,5-fiuorouacil plus hydroxycamptothecyi, and the control group received cisplatin,leucorin,5-fiuorouracil without hydroxycamptothecin. The efficacy and toxicity in two groups were evaluated after two cycles.Results:The overall response was 48.8% in the treatment group and 32.6% in control group. There was significant difference between the two groups. The major toxicity of two groups included anorexia, vomiting, leukopenia, but there was significant difference between the two groups.Conclusion:The combination chemotherapy with HCPT is effective and safe for gastroenteric carcinoma.
【CateGory Index】： R735