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《LiShiZhen Medicine and Materia Medica Research》 2005-09
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Antiviral Effect of Polysaccharide from Scutellaria Baicalensis Georgi on Porcine Respiratory and Reproductive Syndrome Virus

ZHANG Dao-guang~1, Jimmy Kwang~2, PAN Sheng-i~(1*)(1.School of Pharmacy, Fudan University, Shanghai 200032, China; 2.Temasek Life Sciences Laboratory, National University of Singapore)  
Objective:To show that polysaccharide from Scutellaria baicalensis Georgi has antiviral property by investigating its effect on replication of porcine reproductive and respiratory syndrome virus (PRRSV) in cells of the permanent MARC-145 cell line.Methods:Cells infected with virus were treated with various concentration of polysaccharide and incubated for some hours, then Trypan blue exclusive assay, immunofluorescence assay (IFA), plaque forming assay, polymerase chain reaction (PCR) was performed.Results:Number of plaques, the death rate of cells and percentage of IFA positive cells reduced and band of PCR product became weaker and undetectable with the concentration of polysaccharide increasing after infection with PRRSV. Conclusion:It was indicated that polysaccharide from Scutellaria baicalinsis Georgi could inhibit the replication of virus at cell level.
【Fund】: 复旦大学与新加坡国立大学淡马锡生命科学实验室合作项目(No.03057)
【CateGory Index】: R285
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