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《LiShiZhen Medicine and Materia Medica Research》 2006-02
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Toxicologic Study on Fufang Xiaojingtong Capsule

LI Lan-fang,LI Guo-feng,XIE Li-jun,ZHANG Qin-zeng,LI Cun-man,LIANG Liang,HAO Na,ZHANG Jian-xin(Hebei Academy of Medical Science,Shijiazhuang 050021,China)  
ObjectiveTo abserve the acute toxicity in mice and the long-period toxicity Fufang Xiaojingtong Capsule(FFXT) in rats.MethodsThe maximum administration dosage(MAD) of FFDX were determined by iq administration in mice.80 SD rats were randomly divided into four groups: high,middle,and low dose of FFXT and control group.FFXT was continuously administrated for 90 days.When the experiment was finished and withdrawed for 14 days,rats were killed and the growth condition,blood cell counting and biochemical targets were measured.Histomorphological examination were simultaneously performed.ResultsThe MAD of FFXT by iq administration was greater than 40.0g/kg in mice.In the long-period toxicity test,the weight coefficients of livers,spleens,kidneys and testis were larger in high dose group than that of in control group.The punctiform necrosis in the liver were found in two rats for high dose group.The white pulp cells in spleen were rarefactively distributed in four rats for high dose group.The seminiferous tubule diameter of testis and the amout of seminiferous epithelial cells increased in male rats.Focal in terstitical cells of testis were propagated in male rats for middle dose group.The weight coefficients of testis were larger only in high dose group than control group at the 14 days after withdrawal.ConclusionIt could be concluded that FFXT is safe to be administrated in the dose prescribed.
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Lan-fang1,TONG Ji-ming2,XIE Li-jun1,LI Guo-feng1,HAO Na1,ZHANG Qin-zeng1,WANG Wei1(1.Hebei Provincial Cent for Disease Control and Prevention,Shijiazhuang 050021,Hebei;2.Chengde Medical College,Chengde 067000,Hebei,China);Study on mutagenicity of fufang xiaojingtong capsules[J];Carcinogenesis,Teratogenesis & Mutagenesis;2010-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhao Xiuwen (Office of Drug Evaluation, Ministry of Health, Beijing);Technical Requirements for Toxicological Test of New Drugs[J];;1988-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIANG Hai-ying, ZHANG Xiao yuan, LIANG Song ping (Laboratory of Protein Chemistry, College of Life sciences, Hunan Normal University, Changsha 410081, China);THE STUDY ON MUTAGENICITY OF HUWEN ANALGESIC PEPTIDE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-03
2 LIU Xiao_qiu, WANG Rong_xian, TIAN Qing_wei(Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 300192 , China);MUTAGENICITY RESEARCH OF No.Ⅱ DRUG[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-01
3 MEI Shu-jiang,LIU Ya,WANG Bao- Gui,et al(1.Department of biiology,Shantou University Medical College,Shantou 51503 1,China;2.College o f Preventive Medicine,Jilin University,Changchun 130021, China;3.Health Supervision Office of Changchun Health Bureau Changchun 130021,China);STUDY ON ACUTE TOXICITY AND MUTAGENTICITY OF POLYOXOANIONS α-K_8H_2[SiW_9Ti_3O_40]·15H_2O[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
4 LIAO Xue1, WANG Jie1, SONG Hong-yu1, et al(1.National Research Center for New Drug Safety Evaluation ,Shenyang 110021,China;2.The Ninth Hospital of Shenyang, shenyang 110024,China);STUDY OF TER ATOGENICITY OF PIOGILISTAZONE HYDROCHLORIDA IN RATS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
5 LIU Yong-xue,WANG Qiong,GAO Pei-yong (Department of Pharmacology and Toxicology,Beijing Institute of Radiation Medicine,Beijing100850,China);Examination of the Mutagenetic Effect of the Recombinant Staphylokinase[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-05
6 YU Yan 1 ,LIN Fei 2 ,ZHANG Rui-juan 1 ZHANG Zhen-jun 1 ,LI An-jing 1 (1.College of Medical Science,Xi'an Jiaotong University,Xi'an 710061,Shanxi China;2.Assessment Institute of Drugs and Biology Products of China,Beijing100050,China);The Toxicity Study of Recombinant Human Glucagon-like Peptide on Rats During the Period of Sensitive Teratogenesis[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-03
7 LIN Fei 1 ,LU Lian 1 ,YANG Xu-qing 2 ,CUI Wei-chuan 2 ,WANG Feng-min 2 (1.National Institute for the Control of Pharmaceutical and Biological Products,Beijing100050,China;2.The Science System Corporation of Beijing Xingda,Beijing100081,China);The Comparison Study of Major Target Organ Hurt Induced by Dicycloplatin and Its Derivates in Rats[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-05
8 PAN Jing-yuan,QIU Yin-sheng,YAN Han-chi,LING Sa (Center of Pharmacology and Toxicology,Hubei Pharmaceutical Industry Research Institute,Wuhan430061,Hubei,China);Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
9 SUN Xiao-ying 1 ,ZHANG Zhen-jun 1 ,BIAN Xue-feng 2 , CHEN Qing 1 ,YU Yan 1 (1.Department of Environmental Health,Xi'an Jiaotong University,Xi'an710061,China;2.Department of Health Statistics,Xi'an Jiaotong University,Xi'an710061,Shaanxi, China);Study on the Teratogenic Effects of Pseudoephedrine in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
10 WEI Xian-fei,TANG Rong-lan,GAN Yun-sheng,LUO Feng-jiao (Liuzhou Medical College, Liuzhou, Guangxi 545006, China);The Toxicity Attenuation and Antimutagenic Effect of Health-preserving Cigarettes Made From Chinese Herbal Medicine[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-01
China Proceedings of conference Full-text Database 2 Hits
1 LIU Xiaoqiu, HAN Ying, SHEN Xiu, ZHAO Ajin, ZHOU Zewei ( Institute of Radiation Medicine, Chinese Academy of Medical Sciences , Peking Union Medical College, Tianjin 300192, China);Mutagenicity Research of NiKeAn[A];[C];2010
2 LIU Chun,ZHAO Yu-mei (Hainan Provincial Institute for Drug Control,Haikou 570216,China);Safety study on local application of Fukunqing pill[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 YANG Jian-yi,GAO Bao-zhen,LI Li,WANG Wen-juan,GUO Hong-gang,BIAN Si-cheng(Department of Biology,Shanxi Medical University,Taiyuan 030001,China);Reproductive Cell Toxicity of Glycosides of Tripterygium Wilfordii Hook.f on Male Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
2 CAO Xiang-yu1,2,LIU Jian-li2,LIU Chang-jiang1,,WANG Xue1,GUO Wei-wei1(1.College of Food Science,Shenyang Agricultural University,Shenyang 110161,China;2. School of Life Science,Liaoning University,Shenyang 110036,China);Toxicity Study and Safety Assessment of Wheat Bran Peptide[J];Food Science;2008-08
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