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Effect of Flavonoids in Fructus Paulowniae on Airway Allegic Inflammation in Guinea Pigs with Bronchial Asthma

CHEN Bao-hong1,LI Ying-chao2,ZHAO Yi-hong2,FU Man-hua3(1.Second Affiliated Hospital of Luohe Medical College,Luohe 462300,China;2.Pharmaceutical Institute of Zhengzhou University,Zhengzhou 450052,China;3.The Traditional Chinese Medical Institute of Henan,Zhengzhou 450052,China)  
Objective This study was designed to investigate the effects of flavonoids in Fructus Paulowniae on IAR and LAR.Methods An guinea pig asthmatic model,induced by OVA was administered by intragastric gavage(ig) with different doses of flavonoids in Fructus Paulowniae.The latent period,the number of acidophils and the Eotaxin in bronchoalveolar lavage fluid(BALF) were observed. Results The flavonoids in Fructus Paulowniae could delay the latent period of airway inflammation significantly.The number of acidophils and total white blood cell in bronchoalveolar lavage fluid(BALF) was restrained by flavonoids in Fructus Paulowniae.In addition,the flavonoids in Fructus Paulowniae could inhibit the overexpression of Eotaxin in the trachea epithelium.Conclusion The results suggest that flavonoids in Fructus Paulowniae can antagonize airway inflammation by inhibiting the overexpression of the Eotaxin in trachea epithelium.
【CateGory Index】: R285.5
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