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《Lishizhen Medicine and Materia Medica Research》 2007-06
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Effects of Guanxinkang Capsules on Nitric Oxide and Endothelin in Myocardium Damaged Rats Induced by Acute Myocardial Ischemia

PAN Zhi1,DUAN Fu-jin2,WEI Xiong-hui1(1.Department of Applied Chemistry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;2.Heilongjiang University of Chinese Medicine and Materia Medica,Harbin 150040,China)  
Objective To evaluate the role of nitric oxide(NO) and endothelin(ET) in the protective effect of Guanxinkang Capsules in myocardium damaged rats.Methods 30 male wistar rats were randomly divided into 3 groups,control group(n= 10),acute myocardial ischemia group(n = 10) and Guanxinkang Capsules group(n= 10).During the experiment, electrocardiography and serum CK,CK-MB and LDH were compared among the 3 groups.The levels of NO and ET in serum,myocardium were also measured.Results The rising degree of ST-T obviously decreased in acute myocardial ischemia rats treated with Guanxinkang Capsules.The levels of serum CK,CK-MB and LDH,all decreased compared with model group(P0.01).In addition,the NO levels in serum and myocardium increased significantly,while the ET level in myocardium markedly decreased compared with model group(P0.05).Conclusion Guanxinkang Capsules can effectively ameliorate the myocardium injury induced by acute myocardial ischemia increase NO and decrease ET.The changes of NO and ET may play a role in the pathogenesis and progress of myocardial injury.
【Fund】: 黑龙江省科学技术厅资助项目(No.GB01C10702)
【CateGory Index】: R285.5
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