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Inhibitory Effect of TSYZ Formula on Neuronal Apoptosis of AD Model Mice

LUO Xi-rong LI Hong-yan HAO Xiao-yan GUAN zhi-zhong LUO Jun~* (Guiyang Medical College,Guiyang 550004,China)  
Objective To study the effect of TSYZ formula on neuronal apoptosis and anti-oxidation of aged dementia model mice.Methods The aged dementia models were induced by long-term i.g AlCl_3.TUNEL was used to detect neuronal apopto- sis,and cerebral SOD and MDA were studied.Results Typical apoptosis characters were markedly caused in model group,mean- while the abilities of SOD decreased and the quantities of MDA increased remarkably.The TSYZ formula groups obviously inhibi- ted neuronal apoptosis,increased the activity of SOD and lowered the quantities of MDA(P0.05 or P0.01).Conclusion It is suggested that the inhibitory effects of TSYZ formula on neuronal apoptosis and anti-oxidation are remarkable.The macha- nisms maybe that the protective effects of TSYZ formula on the ability of learning and memory of AD model mice.
【Fund】: 贵州省中药现代化专项资助项目(No.[2004]40号)
【CateGory Index】: R285.5
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