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《Lishizhen Medicine and Materia Medica Research》 2007-10
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Protective Effects of Breviscapine on Cerebral Hypoxia in Mice

JIANG Zhao-rui1,LI Jing1,HAN Zhi-feng1,SHANG Ya-zhen2(1.Department of Traditional Chinese Medicine,Chengde Medical College,Chengde,Hebei 067000,China;2.Institute of Traditional Chinese Medicine,Chengde Medical College,Chengde,Hebei 067000,China)  
Objective To study the protective effects of breviscapine on cerebral hypoxia in mice.Methods The protective effects on cerebral hypoxia were investigated on survival time after ip 200 mg/kg NaNO2 and gasping duration after decapitation in mice following 7d consecutive oral administration of breviscapine(10,20 mg/kg,ig).Results Administration of breviscapine(10 mg/kg,ig) for 7 d could significantly prolong survival time after ip NaNO2 in mice.Compared with control group,the survival time after ip NaNO2 was prolonged 83.9 % and 4.93 %.Administration of breviscapine(10,20 mg/kg,ip) for 7d could significantly prolong gasping duration after decapitation in mice.The gasping duration after decapitation of the two experiment groups were found 1.60 and 1.30 times of the control group respectively.Conclusion Breviscapine has significant protective effects on cerebral hypoxia in mice.
【Fund】: 承德医学院大学生科研资助项目(No.2006013)
【CateGory Index】: R285.5
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