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Antagonism of Cordyceps Polysaccharides to Photoaging Fibroblasts Induced by 8-MOP/UVA

LI Hua,YE Ting-jie,LI Bo-qing,YING Xin-ping(Department of Biology,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China)  
Objective To observe the protective action of cordyceps polysaccharides(CP)on photoaging skin fibroblasts.Methods Photoaging skin fibroblast models were induced by 8-MOP/UVA.Cordyceps polysaccharides was administrated before 8-MOP/UVA.HE stained,MTT,hydroxyproline(HYP),MDA and SOD quantitant were used to test the effects of cordyceps polysaccharides.Results Cell crimple,condensation of nuclear chromatin in 8-MOP/UVA model group were observed.Compared with model group,cp groups alleviate cell crimple could increase the activity of cell,decrease the content of MDA,and increase the level of HYP and the activity of SOD.Conclusion Cordyceps polysaccharides has protective effect on photoaging skin fibroblast.
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