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《Lishizhen Medicine and Materia Medica Research》 2009-06
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Protective Effect of Curcumin Solid Dispersion on Acute Liver Injury Induced by Carbon Tetrachloride in Mice

HAN Gang1,WAN Hong2,ZHAI Guan-yu1,FAN Ying1(1.Pharmaceutical Department of North China Coal Medical University,Tangshan 063000,China;2.North China Coal Medical University,Qinhuangdao Branch College,Qinhuangdao 066000,China)  
Objective To study the effects of curcumin solid dispersion on acute liver injury of mice induced by carbon tetrachloride(CCl4).MethodsThe curcumin solid dispersion was prepared with excipient of polyvinylpyrrolidone.Fifty mice were randomly divided into five groups: control group,carbon tetrachloride group,curcumin group,low and high dosage of curcumin solid dispersion groups.The acute liver injury model was established by intraperitoneal administered carbon tetrachloride.The contents of alanine aminotransferase(ALT),asparate aminotransferase(AST) in serum and the activity or content of superoxide dismutase(SOD) and malondialdehtyde(MDA) in liver were measured to evaluate the protective effect of curcumin solid dispersion.ResultsThe curcumin solid dispersion significantly decreased serum ALT activity,liver MDA content and SOD activity in CCl4 poisoned mice.ConclusionThe curcumin solid dispersion protects mice against liver injury induced by CCl4.
【Fund】: 中国煤矿尘肺治疗基金(No.2006-11)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
1 Liang Guang~(1,2),Tian Jilai~1,Shao Lili~1,Yang Shulin~2,Li Xiaokun~(1*)(~1School of Pharmacy,Wenzhou Medicinal College,Wenzhou 325035;()~2Institute of Biotechnology,Nanjing University of Science and Technology, Nanjing 210094);Progress in the Research on SAR and Development of Antitumor Curcuminoids[J];Chemistry;2008-02
2 WANG Hai-hui CHENG Yang Institute of Liver Disease,Shanghai University of Traditional Chinese Medicine;Pharmacological Research Progress on Curcumin[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2007-06
Chinese Journal Full-text Database 10 Hits
1 KANG Ju-fang1, ZENG Ming1, GUAN Lan1, GUO Jin-min2, CHEN Peng2, ZHONG Cai-gao1(1. Department of Toxicology,School of Public Health,Central South University, Changsha 410078; 2.Department of Preventive Medicine, School of Public Health, Central South University, Changsha 410078, China);Study on Mutagenesis Induced by Glyphosate in Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-03
2 LIU NING,WANG CHUN-BO,WANG SHU-PING(Qingdao University Medical College,Qingdao 266021,China);SAFETY EVALUATION OF SWEET-POTATO ANTHOCYANIN[J];Acta Academiae Medicinae Qingdao Universitatis;2008-02
3 GAO Na-na,CHANG Qing,CHEN Li,LI Xue-bin,Yang Xu,DING Shu-mao.College of Life Sciences,Central China Normal University,Wuhan 430079,China;Effect of micronucleus rate in peripheral lymphocytes and liver cells of mice exposed to gaseous formaldehyde[J];Journal of Public Health and Preventive Medicine;2008-03
4 (ZHANG Nan1,YUN Keming1,SUN Junhong1,WEI Zhiwen1,HE Wenyan1,GUO Zheng2/1.Department of Forensic Toxicology,School of Forensic Medical University,Taiyuan 030001,China;2.Second Affiliated Hospital,School of Forensic Medical University,Taiyuan 030001,China);Study on the postmortem distributions of lidocaine in dogs after a subarachnoid administration and an intravenous administration[J];Chinese Journal of Forensic Medicine;2009-01
5 HE Zhong-wen,XI Yi-long,CHEN Yan(Provincial Key Laboratory of Biotic Environment & Ecological Safety in Anhui,College of Life Sciences,Anhui Normal University,Wuhu 241000,China);Comparison of Toxicity of Aldrin on Moina Macrocopa in Two Different Test Mediums[J];Journal of Anhui Normal University(Natural Science);2009-04
6 XIA Bin,CHEN Jianwei,ZHOU Yikai,et al.Ministry of Education Key Lab of Environment and Health,Department of Occupational and Environmental Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China;Exploration of Evaluation Index System of Health Damage of Environmental Pollution[J];Chinese Journal of Social Medicine;2009-04
7 SUN Jianping1,2,ZHENG Ping1,HU Baolan1,YU Yi11. Department of Environmental Engineering,Zhejiang University,Hangzhou 3100292. College of Biology and Environmental Engineering,Zhejiang Shuren University,Hangzhou 310015;Cumulative inhibition of heavy metals to anaerobic digestion of piggery wastewater[J];Acta Scientiae Circumstantiae;2009-08
8 ZHANG Qing-bi CHEN Zhi-qun GAN Zhong-lin et al. Teaching and Research Section of Occupational and Environmental Health Department of Public HealthLuzhou Medical College Luzhou Sichuan 646000 China;Mutagenicity of Organic Extract From Drinking Water in a Certain City[J];Journal of Environment and Health;2005-04
9 YAN Jin,LIU Ying-shuai,CHI Xin,et al.Department of Occupation Health Medical College,Wuhan University of Science and Technology,Wuhan,Hubei 430080,China;Effect of Air Formaldehyde Exposure of Medical Students on DNA-Protein Crosslinks in Their Buccal Mucosa Cells[J];Journal of Environment and Health;2005-06
10 QIAN Li-qun, JIN Yan-feng, LIU Feng-lian, et al. School of Public Health, Ningxia Medical College, Yinchuan, Ningxia 750004, China;Effect of Zinc on the Growth and Anti-oxidation Function of Rats[J];Journal of Environment and Health;2006-03
China Proceedings of conference Full-text Database 1 Hits
1 Zhang Jin-zhou,Shen Zhi-guo,Zhuang Zhi-xiong,Yang Lin-qing Shenzhen Center for Disease Prevention and Control,Shenzhen 518020,China;Study on the damage mechanism of 1,2-Dichloroethane to rat liver cell[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Cheng Yang,Ping Jian,Xu Lieming,et al.Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203,China;Curcumin inhibits the activation marker of hepatic stellate cells by up-regulating the peroxisome proliferator-activated receptorγ.[J];Chinese Journal of Practical Internal Medicine;2006-24
2 WANG Qi, WANG Kui 1 (School of Public Health? 1School of Pharmaceutical Sciences, Peking University, Beijing 100083);Metabolism of curcumin[J];Chinese Pharmacological Bulletin;2003-10
3 CHEN Hua, XUE Chang-gao, CHEN Tie-hui, WANG Jia-li, SUN Chang-sheng (Toxicological Laboratory of Chinese Medicine, School of Public Health, Fujian Medical University, Fuzhou 350004,China);Chemopreventive effect of curcuma and curcumin on liver injury induced by microcystins in mice[J];Chinese Pharmacological Bulletin;2005-12
4 HAN Gang, HAN Xue cheng, ZHANG Wei guo (Pharmaceutical Department, North China Coal Mine Medical College Tangshan 063000, China);Study on applying surface active agent to increase extractive rate of curcumin[J];Chinese Traditional Patent Medicine;2004-04
5 HAN Gang, AN Jing *, WANG Bing-qiang *, SUN Hai-yan * (North China Coal Medical College, Tangshan 063000, China);Quality standard for Tongmai Jiangzhi Capsules[J];Chinese Traditional Patent Medicine;2005-07
6 Han Gang, Xu Jianhua, Li Weina, Ning Chunling (Pharmaceutical Department, North China Coal Mine Medical College, Tangshan 063000);Study on Preparation of the Inclusion Compound of Curcumin with β-Cyclodextrin[J];Journal of Chinese Medicinal Materials;2004-12
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