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《Lishizhen Medicine and Materia Medica Research》 2009-06
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Protective Effect of Curcumin Solid Dispersion on Acute Liver Injury Induced by Carbon Tetrachloride in Mice

HAN Gang1,WAN Hong2,ZHAI Guan-yu1,FAN Ying1(1.Pharmaceutical Department of North China Coal Medical University,Tangshan 063000,China;2.North China Coal Medical University,Qinhuangdao Branch College,Qinhuangdao 066000,China)  
Objective To study the effects of curcumin solid dispersion on acute liver injury of mice induced by carbon tetrachloride(CCl4).MethodsThe curcumin solid dispersion was prepared with excipient of polyvinylpyrrolidone.Fifty mice were randomly divided into five groups: control group,carbon tetrachloride group,curcumin group,low and high dosage of curcumin solid dispersion groups.The acute liver injury model was established by intraperitoneal administered carbon tetrachloride.The contents of alanine aminotransferase(ALT),asparate aminotransferase(AST) in serum and the activity or content of superoxide dismutase(SOD) and malondialdehtyde(MDA) in liver were measured to evaluate the protective effect of curcumin solid dispersion.ResultsThe curcumin solid dispersion significantly decreased serum ALT activity,liver MDA content and SOD activity in CCl4 poisoned mice.ConclusionThe curcumin solid dispersion protects mice against liver injury induced by CCl4.
【Fund】: 中国煤矿尘肺治疗基金(No.2006-11)
【CateGory Index】: R285.5
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