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Preparation and Evaluation of Puerarin Nanoemulsion for Injection

LI Jun1,2,REN Fen2,JIANG Bi-rong3(1.Key Laboratory of Tropic Biological Resourcs(Hainan Univesity),Ministry of Education,Hainan Haikou,570228,China;2.College of Oceanology,Hainan University,Hainan Haikou 570228,China;3.College of Civil Enginerening and Architecture Hainan University,Hainan Haikou 570228,China)  
Objective To study nanoemulsion of puerarin for injection.MethodsSingle factor screening and phase diagram were used to optimize preparation process,and physicochemical properties,shape,size,size distribution and content of puerarin nanoemulsions were invesegated.ResultsOptimum oil,surfactant and cosurfactant were soybean oil,phospholipase and sorbitol with their optimum proprotion of 1.6∶20∶20.The puerarin emulsion for injection had 2.5% puerarin,and appeared yellow,transparent.Droplets in emulsions showed spherical with average size 32.4 nm,conductivity 69 μs·cm-1,viscosity 17.8 mPa·s,refractive index 1.3815 and good stagility.ConclusionPuerarin nanoemulsions were developed successfully.
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