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《Lishizhen Medicine and Materia Medica Research》 2009-11
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Experimental Study of Alcohol Extract from Pepper on Pharmacology

DENG Yong-kun,DONG Shou-tang,WANG Yin-hui,LI Hui(School of Pharmacology,Dali College,Dali,Yunan 671000,China)  
Objective To investigate the pharmacological effect of alcohol extract from pepper on topical application.Methods Two experimental models including xylene-induced ear edema in mice and histamine phosphate induced-foot pruritus in guinea pigs were employed to evaluate topically anti-inflammatory and antipruritic action of 70% alcohol extract from pepper.Internal diameters of auric arterioles and venules in mice were measured initially and then 5,10 and 20min after application of 70% alcohol extract from pepper and again 5,10,15 and 20 min after ip Adrenaline with image analysis system.Simultaneously blood flow state in auric venules was observed.Results Topical administration of 70% alcohol extract from pepper significantly inhibited ear edema induced by xylene,significantly increased threshold quantity of histamine phosphate with which elicited pruritus in guinea pigs,significantly dilated auric arterioles and venules in mice,speeded up blood flow rate of venules.Furthermore,it inhibited adrenaline-induced contraction of arterioles and venules as well as the reduction of blood flow rate of venules.Conclusion 70% alcohol extract of pepper has pharmacological activities of anti-inflammation,alleviating itching and improving microcirculation.
【Fund】: 云南省教育厅科研基金(No.04Z167C)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 3 Hits
1 Liu Jiangang, Xu Xiusen, Cui Yanying, et al/Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091;Effect on Jinguning Lotion in Rats Auricle with Experimental Distubance of Microcirculation[J];CHINESE JOURNAL OF MICROCIRCULATION;1999-02
2 PAN Jing-yuan, QIU Yin-sheng, YAN Han-chi, LING Sha (Center of Pharmacology and Toxicology,Hubei Pharmaceutical Industry Research Institute,Wuhan 430061,China);The anti-itching and anti-hypersensitivity effects of Doxepin hydrochloride cream[J];Chinese Pharmacological Bulletin;2005-12
3 LEI Xiao-ming,LIU Wen-tai,LI Li-hua,ZENG Qian (Basic Medicine College,Hebei Medical University,Shijiazhuang 050091 ,China);Alleviating Pruritus and Deswelling Mechanisms of Kekey ang Liniment[J];China Journal of Basic Medicine In Traditional Chinese Medicine;2005-09
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Liu Wentai,Li Lihua,Liu Jinwei,et al (050091) Medical University,Shijiazhuang$$$$;CLINICAL RESEARCH OF TREATING SKIN ITCH WITH KE KE YANG[J];HEBEI MEDICINE;1999-10
2 JH Xu; YX He; ST Shu and LM Wang(Department of Pharmacology,Faculty of Pharmaceutical Sciences,Zhejiang Medical University, Hangzhou 310031);AN ANIMAL MODEL FOR SCREENING OF ANTIALLERGIC AND ANTIPRURITIC DRUGS[J];ACTA PHARMACEUTICA SINICA;1996-06
3 LIN Yu-Hong, XU Jian-Hua (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Zhejiang Medical University, Hangzhou 310006, China);4-Aminopyridine-induced licking response and histamine liberation in mice[J];中国药理学报(英文版);1994-03
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