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《Lishizhen Medicine and Materia Medica Research》 2009-11
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Experimental Study of Alcohol Extract from Pepper on Pharmacology

DENG Yong-kun,DONG Shou-tang,WANG Yin-hui,LI Hui(School of Pharmacology,Dali College,Dali,Yunan 671000,China)  
Objective To investigate the pharmacological effect of alcohol extract from pepper on topical application.Methods Two experimental models including xylene-induced ear edema in mice and histamine phosphate induced-foot pruritus in guinea pigs were employed to evaluate topically anti-inflammatory and antipruritic action of 70% alcohol extract from pepper.Internal diameters of auric arterioles and venules in mice were measured initially and then 5,10 and 20min after application of 70% alcohol extract from pepper and again 5,10,15 and 20 min after ip Adrenaline with image analysis system.Simultaneously blood flow state in auric venules was observed.Results Topical administration of 70% alcohol extract from pepper significantly inhibited ear edema induced by xylene,significantly increased threshold quantity of histamine phosphate with which elicited pruritus in guinea pigs,significantly dilated auric arterioles and venules in mice,speeded up blood flow rate of venules.Furthermore,it inhibited adrenaline-induced contraction of arterioles and venules as well as the reduction of blood flow rate of venules.Conclusion 70% alcohol extract of pepper has pharmacological activities of anti-inflammation,alleviating itching and improving microcirculation.
【Fund】: 云南省教育厅科研基金(No.04Z167C)
【CateGory Index】: R285.5
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