Mechanism of the Protection of Scutellarin against Immunological Liver Injury Induced by BCG+LPS in Mice

YANG Xiu-fen,GUO Jing-jing(Faculty of Pharmacological Sciences,Guangxi Traditional Chinese Medical University,Nanning 530001,China)  

Objective To investigate the mechanism of the protection of scutellarin against immunological liver injury induced by BCG+LPS in mice according to our previous study.MethodsExperimental immunological liver injury model was created by Calmette-Guerin bacillus vaccine(BCG) and lipopolysaccharide(LPS) in mice.Mice were treated with scutellarin 50,100,200 mg·kg-1 through oral gavage once daily for 12 consecutive days.The level of ALT in serum,the contents or activities of SOD,MDA,GSH-Px,CAT,XOD,NO,total NOS,iNOS,cNOS in liver tissues were monitored.Results Three doses of scutellarin(50,100,200 mg·kg-1) could significantly decrease the level of ALT,significantly increase the activities of CAT,SOD,GSH-Px,and decrease the contents of SOD,MDA,NO in liver tissue.According to NOS analysis,scutellarin could decrease the expression of total NOS and iNOS,but it had no effect on the expression of cNOS.ConclusionThe mechanism of the protection of scutellarin on immunological liver injury induced by BCG+LPS in mice might attribute to preventing lipid peroxidation,reinforcing capability of free radical clearance,adjusting the level of NO in the body.

【Key Words】： Scutellarin Calmette-Guerin bacillus vaccine Lipopolysaccharide Immune Liver injury Antioxidation Nitric oxide
【Fund】： 国家自然科学基金(No.30660228);; 广西教育厅科研项目(No.2004-20);; 广西中医学院高学历科研启动金资助
【CateGory Index】： R285.5

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