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《Lishizhen Medicine and Materia Medica Research》 2011-01
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Antioxidative Effects of Baicalin in vitro

GUO Shao-ying1,CHENG Fa-feng1,ZHONG Xiang-gen1,LU Yi1,SONG Wen-ting2,WANG Qing-guo1(1.School of Preclinical Medicine,Beijing University of Chinese Medicine,Beijing,100029,China;2.Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing,100091,China)  
Objective To explore the antioxidation of baicalin in vitro.Methods The free radical scavenging effects of different concentrations of baicalin were measured with DPPH method.The total antioxidation capability and superoxide anion resistance were detected by kits.The effect of baicalin on xanthine oxidase activity was measured by detecting the content of uric acid produced in xanthine/xanthine oxidase system.Results The total antioxidatve capability of baicalin was significant and showed obvious dose-effect relationship.Baicalin could scavenge free radical and superoxide anion;in addition,it could inhibit the activity of xanthine oxidase,and the content of uric acid,produced in xanthine/xanthine oxidase system,continuously reduced following increasing baicalin concentrations.Conclusion Baicalin is a good antioxidant,which can not only scavenge free radical and superoxide anion directly,but also inhibit xanthine oxidase activity.
【Fund】: 国家自然科学基金(No.90709051);; 重大新药创制科技重大专项(No.2009ZX09102-136)
【CateGory Index】: R285
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